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C-Reactive Protein, but not Low-Density Lipoprotein Cholesterol Levels, Associate with Coronary Atheroma Regression and Cardiovascular Events Following Maximally Intensive Statin Therapy.
CONCLUSIONS: Following 24 months of potent statin therapy, on-treatment CRP levels associated with MACE. Inflammation may be an important driver of residual cardiovascular risk in patients with coronary artery disease despite aggressive statin therapy. CLINICAL TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov. Identifier: NCT000620542. PMID: 24043299 [PubMed - as supplied by publisher]
Source: Circulation - September 16, 2013 Category: Cardiology Authors: Puri R, Nissen SE, Libby P, Shao M, Ballantyne CM, Barter PJ, Chapman MJ, Erbel R, Raichlen JS, Uno K, Kataoka Y, Nicholls SJ Tags: Circulation Source Type: research

Carotid endarterectomy for symptomatic low-grade carotid stenosis
Conclusions: This study shows that CEA is a safe, effective, and durable treatment for patients with symptomatic low-grade carotid stenosis associated with unstable plaque. Patients had excellent protection against further ischemic events and survived long enough to justify the initial surgical risk. Plaque instability seems to play a major part in the onset of ischemic events, regardless the entity of lumen narrowing.
Source: Journal of Vascular Surgery - August 19, 2013 Category: Surgery Authors: Enzo Ballotta, Annalisa Angelini, Franco Mazzalai, Giacomo Piatto, Antonio Toniato, Claudio Baracchini Tags: Clinical research studies Source Type: research

Traditional Risk Factors Are Not Major Contributors to the Variance in Carotid Intima-Media Thickness Clinical Sciences
Conclusions— Vascular risk factors explain only a small proportion of variance in cIMT. Identification of novel genetic and environmental factors underlying unexplained subclinical atherosclerosis is of utmost importance for future effective prevention of vascular disease.
Source: Stroke - July 22, 2013 Category: Neurology Authors: Rundek, T., Blanton, S. H., Bartels, S., Dong, C., Raval, A., Demmer, R. T., Cabral, D., Elkind, M. S. V., Sacco, R. L., Desvarieux, M. Tags: Risk Factors, Imaging, Doppler ultrasound, Transcranial Doppler etc. Clinical Sciences Source Type: research

Progression of asymptomatic carotid stenosis despite optimal medical therapy
Background: Despite level 1 evidence in support of carotid endarterectomy vs medical therapy in selected asymptomatic patients, an alternative posture is that optimal medical therapy (OMT) has not been adequately studied and that such OMT has reduced stroke risk in asymptomatic patients to levels wherein carotid endarterectomy is no longer justified. The goal of this study was to determine the natural history of patients with asymptomatic moderate (50%-69%) carotid artery stenosis (AMCAS) in a contemporary cohort as a function of their associated medical therapy.Methods: Patients with AMCAS determined by duplex ultrasound ...
Source: Journal of Vascular Surgery - June 30, 2013 Category: Surgery Authors: Mark F. Conrad, Valy Baloum, Shankha Mukhopadhyay, Ashu Garg, Virendra I. Patel, Richard P. Cambria Tags: Clinical research studies Source Type: research

Carotid stenting in asymptomatic patients: how to identify patients without symptoms and at high risk for neurologic events.
Abstract During the last 20 years, asymptomatic patients with high-grade carotid stenosis have been treated with carotid endarterectomy and more recently with carotid artery stenting in order to prevent stroke. New, best medical treatment including statins, beta-blockers, antiplatelet therapies, and better diabetes and blood pressure control might reduce the incidence of stroke in this patient population making invasive treatment unnecessary. However, patients with asymptomatic carotid stenosis cannot be considered a homogenous population, and therefore, the therapeutic approach should take into consideration a su...
Source: The Journal of Cardiovascular Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Yamada R, Anderson MB, Guimaraes M, Schönholz C Tags: J Cardiovasc Surg (Torino) Source Type: research

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