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The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
Curr Opin Lipidol. 2023 Jul 28. doi: 10.1097/MOL.0000000000000890. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis.RECENT FINDINGS: A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which leads to increased levels of bacterial lipopolysaccharide in the mucus of the small intestine and in plasma that increase systemic inflammation, and enhance dyslipidemia and aortic atherosclerosis. Decreasing LPA production in enterocytes reduces the impact of the diet. LPA signaling inhibit...
Source: Atherosclerosis - July 27, 2023 Category: Cardiology Authors: Arnab Chattopadhyay Srinivasa T Reddy Alan M Fogelman Source Type: research

Antioxidant action of xanthine oxidase inhibitor febuxostat protects the liver and blood vasculature in SHRSP5/Dmcr rats
CONCLUSIONS: Overall, the XO inhibitor febuxostat exerted protective effects against NASH and atherosclerosis in SHRSP5/Dmcr rats.PMID:37376883 | DOI:10.32725/jab.2023.009
Source: Atherosclerosis - June 28, 2023 Category: Cardiology Authors: Mai Kakimoto Moe Fujii Ikumi Sato Koki Honma Hinako Nakayama Sora Kirihara Taketo Fukuoka Shang Ran Satoshi Hirohata Kazuya Kitamori Shusei Yamamoto Shogo Watanabe Source Type: research

A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice
Front Pharmacol. 2023 May 30;14:1204905. doi: 10.3389/fphar.2023.1204905. eCollection 2023.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial walls that develops at predisposed sites. As a major risk factor for adverse cardiovascular pathology, atherosclerosis can progress to myocardial infarction and stroke, due to the rupture of unstable atherosclerotic lesions. Macrophage uptake of modified lipoproteins and metabolic dysfunction contributes significantly to the initiation and development of atherosclerotic lesions. The cluster of differentiation 36 receptor [CD36 (SR-B2)] plays a key role in ather...
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Jade Gauvin Genevi ève Frégeau Hanan Elimam Liliane M énard David Huynh Catherine L ê Ahsanullah Ahsanullah William D Lubell Huy Ong Sylvie Marleau Source Type: research

Pathways linking aging and atheroprotection in Mif-deficient atherosclerotic mice
FASEB J. 2023 Mar;37(3):e22752. doi: 10.1096/fj.202200056R.ABSTRACTAtherosclerosis is a chronic inflammatory condition of our arteries and the main underlying pathology of myocardial infarction and stroke. The pathogenesis is age-dependent, but the links between disease progression, age, and atherogenic cytokines and chemokines are incompletely understood. Here, we studied the chemokine-like inflammatory cytokine macrophage migration inhibitory factor (MIF) in atherogenic Apoe-/- mice across different stages of aging and cholesterol-rich high-fat diet (HFD). MIF promotes atherosclerosis by mediating leukocyte recruitment, ...
Source: Atherosclerosis - February 16, 2023 Category: Cardiology Authors: Christine Krammer Bishan Yang Sabrina Reichl Simon Besson-Girard Hao Ji Verena Bolini Corinna Schulte Heidi Noels Kai Schlepckow Georg Jocher Georg Werner Michael Willem Omar El Bounkari Aphrodite Kapurniotu Ozgun Gokce Christian Weber Sarajo Mohanta J ü Source Type: research

Dog models of human atherosclerotic cardiovascular diseases
Mamm Genome. 2022 Oct 15. doi: 10.1007/s00335-022-09965-w. Online ahead of print.ABSTRACTCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Eighty-five percent of CVD-associated deaths are due to heart attacks and stroke. Atherosclerosis leads to heart attack and stroke through a slow progression of lesion formation and luminal narrowing of arteries. Dogs are similar to humans in terms of their cardiovascular physiology, size, and anatomy. Dog models have been developed to recapitulate the complex phenotype of human patients and understand the underlying mechanism of CVD. Different methods, inc...
Source: Atherosclerosis - October 15, 2022 Category: Cardiology Authors: Hui Zhao Enqi Liu Yong Q Zhang Source Type: research

Guanmaitong Granule Attenuates Atherosclerosis by Inhibiting Inflammatory Immune Response in ApoE < sup > -/- < /sup > Mice Fed High-Fat Diet
CONCLUSION: Radix notoginseng, Radix salviae liguliobae, and Radix astragali are the main ingredients of GMTG for treating AS. Further, GMTG could regulate the level of serum lipids and inhibit inflammatory immune response, which resulted in anti-AS effects such as plaque stabilization, reduction of plaque burden, and plaque remodeling. GMTG is a promising multi-target treatment for AS.PMID:36148321 | PMC:PMC9489104 | DOI:10.2147/DDDT.S372143
Source: Atherosclerosis - September 23, 2022 Category: Cardiology Authors: Mengqi Yang Huachen Jiao Yan Li Lei Zhang Juan Zhang Xia Zhong Yitao Xue Source Type: research

Hawthorn fruit acid consumption attenuates hyperlipidemia-associated oxidative damage in rats
CONCLUSION: HFA administration can provide health benefits by counteracting the effects of hyperlipidemia caused by an HFD in the body, and the underlying mechanism of this event is closely related to the activation of the Nrf2/HO-1 signaling pathway.PMID:35990322 | PMC:PMC9384962 | DOI:10.3389/fnut.2022.936229
Source: Atherosclerosis - August 22, 2022 Category: Cardiology Authors: Yicheng Feng Shan Gao Ting Zhu Guibo Sun Peisen Zhang Yichun Huang Shuang Qu Xiaomeng Du Dehua Mou Source Type: research

Suppression of nitric oxide synthase aggravates non-alcoholic steatohepatitis and atherosclerosis in SHRSP5/Dmcr rat via acceleration of abnormal lipid metabolism
CONCLUSIONS: NOS inhibition simultaneously aggravates NASH and atherosclerosis via hepatic lipid and cholesterol metabolism.PMID:35819592 | DOI:10.1007/s43440-022-00380-1
Source: Atherosclerosis - July 12, 2022 Category: Cardiology Authors: Ikumi Sato Shusei Yamamoto Mai Kakimoto Moe Fujii Koki Honma Shota Kumazaki Mami Matsui Hinako Nakayama Sora Kirihara Shang Ran Shinichi Usui Ryoko Shinohata Kazuya Kitamori Satoshi Hirohata Shogo Watanabe Source Type: research

IL-19 Regulates Atherosclerotic Plaque Progression via Lymphangiogenesis
CONCLUSION & SUMMARY: These data suggest that IL-19 increases lymphatic vessel formation, potentially allowing RCT to take place to decrease plaque burden in atherosclerosis. Further studies will confirm IL-19's mechanistic pathway in LECs. We will also determine RCT and inflammatory cell trafficking by intravital microscopy. These results have the potential to shift our understanding toward a positive view of the association between the lymphatic system and atherosclerosis.PMID:35554476 | DOI:10.1096/fasebj.2022.36.S1.R5435
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Amanda Peluzzo Kyle Preston Tani Leigh Sheri Kelemen Michael Autieri Source Type: research

A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats.
CONCLUSIONS: SHRSP5/Dmcr rats may be a suitable animal model for elucidating the organ interaction between NASH and cardiac or vascular dysfunction. PMID: 29162773 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice.
CONCLUSIONS: These findings suggest that miR-134 accelerates atherogenesis by promoting lipid accumulation and proinflammatory cytokine secretion via the ANGPTL4/LPL pathway. Therefore, targeting miR-134 may offer a promising strategy for the prevention and treatment of atherosclerotic cardiovascular disease. PMID: 28867683 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - September 6, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research