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Condition: Mania

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Total 407 results found since Jan 2013.

Use of low-dose quetiapine increases the risk of major adverse cardiovascular events: results from a nationwide active comparator-controlled cohort study
World Psychiatry. 2022 Oct;21(3):444-451. doi: 10.1002/wps.21010.ABSTRACTAt standard doses used for schizophrenia or bipolar disorder, quetiapine has been associated with weight gain and increased levels of triglycerides, to-tal cholesterol and low-density lipoprotein (LDL) cholesterol, which are risk factors for cardiovascular morbidity and mortality. However, this drug is also commonly used off-label at low doses for anxiolytic or hypnotic purposes, and its cardiovascular safety at these doses is unknown. We aimed to assess the risk of major adverse cardiovascular events with use of low-dose quetiapine compared to use of...
Source: World Psychiatry - September 8, 2022 Category: Psychiatry Authors: Mikkel H øjlund Kjeld Andersen Martin T Ernst Christoph U Correll Jesper Hallas Source Type: research

Effects of Cerebellar Transcranial Direct Current Stimulation in Patients with Stroke: a Systematic Review
ConclusionsctDCS appears to improve poststroke language and motor dysfunction (particularly gait). However, the evidence for these results was insufficient, and the quality of the relevant studies was low. ctDCS stimulation parameters and individual factors of participants may affect the therapeutic effect of ctDCS. Researchers need to take a more regulated approach in the future to conduct studies with large sample sizes. Overall, ctDCS remains a promising stroke intervention technique that could be used in the future.
Source: The Cerebellum - August 27, 2022 Category: Neurology Source Type: research

IN BRAIN POST-ISCHEMIC PLASTICITY, Na < sup > + < /sup > /Ca < sup > 2+ < /sup > EXCHANGER 1 AND Ascl1 INTERVENE IN MICROGLIA-DEPENDENT CONVERSION OF ASTROCYTES INTO NEURONAL LINEAGE
Cell Calcium. 2022 May 29;105:102608. doi: 10.1016/j.ceca.2022.102608. Online ahead of print.ABSTRACTThe intricate glia interaction occurring after stroke strongly depend on the maintenance of intraglial ionic homeostasis. Among the several ionic channels and transporters, the plasmamembrane Na+/Ca2+ exchanger (NCX) represents a key player in maintaining astroglial Na+ and Ca2+ homeostasis. Here, using a combined in vitro, in vivo and ex vivo experimental strategy we evaluated whether microglia responding to ischemic injury may influence the morphological and the transcriptional plasticity of post-ischemic astrocytes. Astr...
Source: Cell Calcium - June 6, 2022 Category: Cytology Authors: Antonella Casamassa Ornella Cuomo Anna Pannaccione Pasquale Cepparulo Giusy Laudati Valeria Valsecchi Lucio Annunziato Giuseppe Pignataro Source Type: research

The relationship of carotid artery disease with mental and neurocognitive disorders
Psychiatriki. 2022 May 26. doi: 10.22365/jpsych.2022.083. Online ahead of print.ABSTRACTCarotid stenosis constitutes a common vascular disease that significantly affects cerebral blood flow and thus is associated with patients' cognitive functions. Carotid revascularization techniques [carotid endarterectomy (CEA) and carotid artery stenting (CAS)] may benefit cognition, though there are opposing findings, reporting an apparent decrement in cognitive function, no effect, or an apparent improvement after revascularization. A great number of studies are trying to evaluate the effect of carotid revascularization (CEA, CAS) on...
Source: Psychiatriki - May 27, 2022 Category: Psychiatry Authors: Christos Ch Liapis Source Type: research