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Basilar artery occlusion presenting as sudden bilateral deafness: a case report
ConclusionsWhen hearing loss is due to vertebrobasilar occlusive disease, the prognosis is very poor. We suggest that vertebrobasilar stroke be suspected in patients with bilateral sensorineural hearing loss who present with risk factors for stroke such as atrial fibrillation and other neurologic signs.
Source: Journal of Medical Case Reports - March 2, 2021 Category: General Medicine Source Type: research

Interventions for altering blood pressure in people with acute subarachnoid haemorrhage
CONCLUSIONS: Based on the current evidence, there is a lack of information needed to confirm or reject minimally important intervention effects on patient-important outcomes for both induced hypertension and lowered blood pressure. There is an urgent need for trials assessing the effects of altering blood pressure in people with acute subarachnoid haemorrhage. Such trials should use the SPIRIT statement for their design and the CONSORT statement for their reporting. Moreover, such trials should use methods allowing for blinded altering of blood pressure and report on patient-important outcomes such as mortality, rebleeding...
Source: Cochrane Database of Systematic Reviews - November 17, 2021 Category: General Medicine Authors: Mathias Maagaard William K Karlsson Christian Ovesen Christian Gluud Janus C Jakobsen Source Type: research

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage.
CONCLUSIONS: The current evidence does not support the use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage, even in those who have concomitant treatment strategies to prevent cerebral ischaemia. Results on short-term treatment are promising, but not conclusive. Further randomised trials evaluating short-term antifibrinolytic treatment are needed to evaluate its effectiveness. PMID: 23990381 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - August 30, 2013 Category: Journals (General) Authors: Baharoglu MI, Germans MR, Rinkel GJ, Algra A, Vermeulen M, van Gijn J, Roos YB Tags: Cochrane Database Syst Rev Source Type: research

The glymphatic system and its involvement in disorders of the nervous system.
Authors: Toriello M, González-Quintanilla V, Pascual J Abstract The central nervous system was thought to be devoid of lymphatics. Recently, the existence of an authentic brain lymphatic system, known as the glymphatic system, composed of paravascular channels penetrating arterial and venous brain vessels and dural lymphatics cleaning the interstitial space, has been demonstrated. Aquaporin-4, located in astrocyte feet attached to the paravascular spaces, plays a key role in the clearance of waste molecules, such as beta-amyloid or tau proteins. The activity of this system is increased during sleep, mainly in the ...
Source: Medicina Clinica - January 13, 2021 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Shunting outcomes in communicating hydrocephalus: protocol for a multicentre, open-label, randomised controlled trial
Introduction Ventriculoperitoneal shunt (VPS) remains the most widely used methods to treat communicating hydrocephalus. More recently, lumboperitoneal shunt (LPS) has been suggested as a reasonable option in some studies. However, there is lack of high-quality studies comparing these two techniques in order to certain the benefits and harms to use one of these two methods. The purpose of the current study is to determine the effectiveness and safety of the LPS versus the VPS in patients with communicating hydrocephalus. Methods and analysis All eligible patients aged 18–90 years with communicating hydrocephalus wil...
Source: BMJ Open - August 26, 2021 Category: General Medicine Authors: Sun, T., Cui, W., Yang, J., Yuan, Y., Li, X., Yu, H., Zhou, Y., You, C., Guan, J. Tags: Open access, Neurology Source Type: research

Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage
CONCLUSIONS: The current evidence does not support the routine use of antifibrinolytic drugs in the treatment of people with aneurysmal subarachnoid haemorrhage. More specifically, early administration with concomitant treatment strategies to prevent delayed cerebral ischaemia does not improve clinical outcome. There is sufficient evidence from multiple randomised controlled trials to incorporate this conclusion in treatment guidelines.PMID:36350005 | DOI:10.1002/14651858.CD001245.pub3
Source: Cochrane Database of Systematic Reviews - November 9, 2022 Category: General Medicine Authors: Menno R Germans Wouter J Dronkers Merih I Baharoglu Ren é Post Dagmar Verbaan Gabriel Je Rinkel Yvo Bwem Roos Source Type: research