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Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.
Abstract Heat stroke is characterilized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or vehicle (normal saline 1 ml/kg) was administered to the experimental groups of rats. Additional injection was administered immediately after the onset of heat stroke. Immedi...
Source: Chemico-Biological Interactions - January 15, 2017 Category: Molecular Biology Authors: Lin X, Lin CH, Zhao T, Zuo D, Ye Z, Liu L, Lin MT Tags: Chem Biol Interact Source Type: research

Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
Authors: Chen F, Li H, Zhu G, Chen X, Tang Z Abstract The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS. In the HS groups, the ra...
Source: Molecular Medicine Reports - May 13, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Heat shock protein 70 and AMP-activated protein kinase contribute to 17-DMAG-dependent protection against heat stroke.
Abstract Heat shock protein 70 (Hsp70) preconditioning induces thermotolerance, and adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays a role in the process of autophagy. Here, we investigated whether 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17-DMAG) protected against heat stroke (HS) in rats by up-regulation of Hsp70 and phosphorylated AMPK (pAMPK). To produce HS, male Sprague-Dawley rats were placed in a chamber with an ambient temperature of 42°C. Physiological function (mean arterial pressure, heart rate and core temperature), hepatic and intestinal injury, inflammatory mediators...
Source: J Cell Mol Med - May 30, 2016 Category: Molecular Biology Authors: Tsai YC, Lam KK, Peng YJ, Lee YM, Yang CY, Tsai YJ, Yen MH, Cheng PY Tags: J Cell Mol Med Source Type: research

JNK signaling is required for the MIP ‑1α‑associated regulation of Kupffer cells in the heat stroke response.
JNK signaling is required for the MIP‑1α‑associated regulation of Kupffer cells in the heat stroke response. Mol Med Rep. 2017 Jul 05;: Authors: Chen XJ, Tang ZZ, Zhu GG, Cheng Q, Zhang WK, Li HM, Fu W, Lu QP Abstract Severe heat stroke (HS) consists of extreme hyperthermia with thermoregulatory failure, leading to high morbidity and mortality. Liver injury is a complication of HS that is associated with inflammatory responses and Kupffer cells (KCs), which are resident macrophages in the liver that serve as a major source of inflammatory cytokines; however, the association and the underlying mech...
Source: Molecular Medicine Reports - July 6, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Metabolomic profiling identifies a novel mechanism for heat stroke ‑related acute kidney injury
Mol Med Rep. 2021 Apr;23(4):1. doi: 10.3892/mmr.2021.11880. Epub 2021 Jan 28.ABSTRACTHeat stroke can induce a systemic inflammatory response, which may lead to multi‑organ dysfunction including acute kidney injury (AKI) and electrolyte disturbances. To investigate the pathogenesis of heat stroke (HS)‑related AKI, a mouse model of HS was induced by increasing the animal's core temperature to 41˚C. Blood samples obtained from the tail vein were used to measure plasma glucose and creatinine levels. Micro‑positron emission tomography‑computed tomography (micro‑PET/CT), H&E staining and transmission electron ...
Source: Molecular Medicine Reports - March 3, 2021 Category: Molecular Biology Authors: Ling Xue Wenli Guo Li Li Santao Ou Tingting Zhu Liang Cai Wenfei Ding Weihua Wu Source Type: research

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