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Optimization of a Rhabdomyolysis Model in Mice With Exertional Heat Stroke Mouse Model of EHS-Rhabdomyolysis
In conclusion, we made improvements to a stable EHS-induced RM animal model to truly reflect the clinical characteristics of EHS patients. This new model should be helpful in the further study of RM pathogenesis.
Source: Frontiers in Physiology - June 15, 2020 Category: Physiology Source Type: research

Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture
AbstractExertional heat stroke (EHS) and malignant hyperthermia (MH) are life-threatening conditions, triggered by different environmental stimuli that share several clinical symptoms and pathophysiological features. EHS manifests during physical activity normally, but not always, in hot and humid environments. MH manifests during exposure to haloalkane anesthetics or succinylcholine, which leads to a rapid, unregulated release of calcium (Ca2+) within the skeletal muscles inducing a positive-feedback loop within the excitation –contraction coupling mechanism that culminates in heat stroke-like symptoms, if not rapidly r...
Source: Sports Medicine - July 5, 2020 Category: Sports Medicine Source Type: research

Case report of nuclear medicine, bone scan imaging on a patient with heat stroke induced rhabdomyolysis
J Nucl Med Technol. 2021 Jul 30:jnmt.121.262501. doi: 10.2967/jnmt.121.262501. Online ahead of print.ABSTRACTBone scan continues to be the second greatest-volume nuclear imaging procedure, offering the advantage of total body examination, low cost, and high sensitivity not only for metastatic lesions but also benign conditions. Its power rests in the physiological uptake and pathophysiologic behavior of 99m technetium (99m-Tc) diphosphonates. 1 The localization of radiotracers in damaged skeletal muscles is because calcium builds up in them and provides a site for radiotracer deposition when combined with phosphate.1 In ca...
Source: Journal of Nuclear Medicine Technology - July 31, 2021 Category: Nuclear Medicine Authors: Jitesh Dhingra Yoram Baum Source Type: research

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