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Condition: Heart Valve Disease
Education: Study

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Total 330 results found since Jan 2013.

One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloon-expandable valve: the S3U registry
CONCLUSIONS: Compared with the S3, the S3U transcatheter heart valve was associated with similar 1-year clinical outcomes but reduced rates of mild PVL.PMID:36880333 | DOI:10.4244/EIJ-D-22-01022
Source: EuroIntervention - March 7, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Stefano Cannata Caterina Gandolfo Flavio L Ribichini Nicolas van Mieghem Sergio Buccheri Marco Barbanti Sergio Berti Rui Campante Teles Antonio L Bartorelli Giuseppe Musumeci Tommaso Piva Luis Nombela-Franco Ketty La Spina Tullio Palmerini Rik Adrichem Au Source Type: research

New VOYAGER PAD Analysis Confirms Consistent Benefit of XARELTO ® (rivaroxaban) Plus Aspirin Following Lower Extremity Revascularization (LER)
TITUSVILLE, NJ, March 5, 2023 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from a new prespecified analysis from the Phase 3 VOYAGER PAD clinical trial reinforcing the benefits of the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) over standard of care (aspirin alone), demonstrating consistent benefit at 30 days, 90 days and up to three years following LER in patients with PAD. Lower extremity revascularization, also called peripheral revascularization, is a procedure that restores blood flow in blocked arteries or veins. This analysis of ...
Source: Johnson and Johnson - March 5, 2023 Category: Pharmaceuticals Tags: Latest News Source Type: news

The efficacy and safety of direct oral anticoagulants versus vitamin K antagonists in patients with left-sided bioprosthetic heart valves and atrial fibrillation: a systematic review and meta-analysis
ConclusionOur meta-analysis demonstrated that in patients with AF and BHV, compared with VKAs, using DOACs was associated with reduced stroke and major bleeding events without an increase of all-cause mortality and any bleeding. In the population younger than 75  years old, DOAC might be more effective in preventing cardiogenic stroke.
Source: European Journal of Clinical Pharmacology - February 16, 2023 Category: Drugs & Pharmacology Source Type: research

Direct oral anticoagulants in patients with a left-sided bioprosthetic heart valve: a systematic review and meta-analysis
AbstractTo compare the efficacy/effectiveness and safety of DOACs versus VKAs in patients with a previously and newly surgically implanted BHV with or without AF. A systematic search on MEDLINE and EMBASE was performed till November 2022. Treatment effects were estimated with relative risk (RR) and 95% confidence intervals (CIs). Statistical heterogeneity was assessed with theI2 statistic. Four randomized controlled trials (RCTs), 2 subgroup analysis from ARISTOTLE and ENGAGE-AF-TIMI 48 and 4 observational studies were included for a total of 5808 patients, 1893 on DOACs and 3915 on VKAs. AF prevalence was 98.28%. In the o...
Source: Internal and Emergency Medicine - February 7, 2023 Category: Emergency Medicine Source Type: research

Reduced dose direct oral anticoagulants compared with warfarin with high time in therapeutic range in nonvalvular atrial fibrillation
The objective of this study was to compare effectiveness and safety between reduced dose DOACs and high TTR warfarin treatment (TTR  ≥ 70%) in NVAF. A Swedish anticoagulation registry was used in identifying eligible patients from July 2011 to December 2017. The study cohort consisted of 40,564 patients with newly initiated DOAC (apixaban, dabigatran, or rivaroxaban) (11,083 patients) or warfarin treatment (29,481 patients ) after exclusion of 374,135 patients due to not being warfarin or DOAC naïve, not being prescribed reduced dose, having previous mechanical heart valve (MHV), or being under 18 years old. The me...
Source: Journal of Thrombosis and Thrombolysis - January 6, 2023 Category: Hematology Source Type: research

Nationwide experience with transcarotid transcatheter aortic valve implantation: Insights from the POL-CAROTID registry
CONCLUSIONS:: The results of the study indicated that the first cohort of transcarotid transcatheter heart valves of second-generation implantations in Poland were associated with a similar prognosis to TF-TAVI with regard to safety and feasibility. TC access may be considered an optimal alternative for patients, in whom the TF approach is precluded.PMID:36594529 | DOI:10.33963/KP.a2022.0288
Source: Kardiologia Polska - January 3, 2023 Category: Cardiology Authors: Radoslaw Wilimski Zenon Huczek Kajetan Grodecki Janusz Kochman Bartosz Rymuza Wojciech Wojakowski Damian Hudziak Dariusz Jagielak Jerzy Sacha Marek Grygier Andrzej Walczak Piotr Hendzel Romuald Cicho ń Marcin Grabowski Mariusz Ku śmierczyk Source Type: research