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Genes, Vol. 13, Pages 1664: Expression Profile of New Gene Markers Involved in Differentiation of Canine Adipose-Derived Stem Cells into Chondrocytes
artosz Kempisty The interest in stem cell research continuously increased over the last decades, becoming one of the most important trends in the 21st century medicine. Stem cell-based therapies have a potential to become a solution for a range of currently untreatable diseases, such as spinal cord injuries, type I diabetes, Parkinson’s disease, heart disease, stroke, and osteoarthritis. Hence, this study, based on canine material, aims to investigate the molecular basis of adipose-derived stem cell (ASC) differentiation into chondrocytes, to serve as a transcriptomic reference for further research aiming...
Source: Genes - September 16, 2022 Category: Genetics & Stem Cells Authors: Maurycy Jankowski Mariusz Kaczmarek Grzegorz W ąsiatycz Aneta Konwerska Claudia Dompe Dorota Bukowska Pawe ł Antosik Paul Mozdziak Bartosz Kempisty Tags: Article Source Type: research

GSE178936 Longitudinal dynamics of clonal haematopoiesis identifies gene-specific fitness effects
Contributors : Neil A Robertson ; Eric Latorre-Crespo ; Maria Terradas-Terradas ; Linus J Schumacher ; Kristina Kirschner ; Tamir ChandraSeries Type : OtherOrganism : Homo sapiensThe prevalence of clonal haematopoiesis of indeterminate potential (CHIP) in healthy individuals increases rapidly from age 60 onwards and has been associated with increased risk for malignancy, heart disease and ischemic stroke. CHIP is driven by somatic mutations in stem cells that are also drivers of myeloid malignancies. Since mutations in stem cells often drive leukaemia, we hypothesised that stem cell fitness substantially contributes to tra...
Source: GEO: Gene Expression Omnibus - May 3, 2022 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research

Coding and non-coding nucleotides': The future of stroke gene therapeutics
Genomics. 2021 Mar 4:S0888-7543(21)00084-7. doi: 10.1016/j.ygeno.2021.03.003. Online ahead of print.ABSTRACTStroke is the foremost cause of death ranked after heart disease and cancer. It is the fatal life-threatening event that requires immediate medical admissions to overcome following morbidity and mortality. The therapeutic advances in stroke therapy have been manipulated with diverse paths for last 5 years. Recent research and clinical trials have investigated a variety of anti-stroke agents including anti-coagulants, cerebro-protective agents, antiplatelet therapy, stem-cell therapy, and specified gene therapy. In re...
Source: Genomics - March 7, 2021 Category: Genetics & Stem Cells Authors: Vishal Chavda Kajal Madhwani Source Type: research