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Influence of Exercise Training on the Left Atrium:Implications for Atrial Fibrillation, Heart Failure and Stroke
Am J Physiol Heart Circ Physiol. 2023 Jul 28. doi: 10.1152/ajpheart.00322.2023. Online ahead of print.ABSTRACTThe left atrium (LA) plays a critical role in receiving pulmonary venous return and modulating left ventricular (LV) filling. With the onset of exercise, LA function contributes to the augmentation in stroke volume. Due to the growing focus on atrial imaging, there is now evidence that structural remodelling and dysfunction of the LA is associated with adverse outcomes including incident cardiovascular disease. In patients with established disease, pathological changes in atrial structure and function are associate...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 28, 2023 Category: Physiology Authors: Adrian Elliott Jonathan Ariyaratnam Erin J Howden Andr é La Gerche Prashanthan Sanders Source Type: research

The protective role of sex hormones in females and exercise prehabilitation in males on sternotomy-induced cranial hypoperfusion in aortic banded mini-swine
During cardiac surgery, specifically sternotomy, cranial hypoperfusion is linked to cerebral ischemia, increased risk of perioperative watershed stroke, and other neurocognitive complications. The purpose of this study was to retrospectively examine the effect of sex hormones in females and exercise prehabilitation in males on median sternotomy-induced changes in cranial perfusion in a large animal model of heart failure. Cranial blood flow (CBF) before and 10 and 60 min poststernotomy was analyzed in eight groups of Yucatan mini-swine: female control, aortic banded, ovariectomized, and ovariectomized + aortic banded; male...
Source: Journal of Applied Physiology - February 28, 2017 Category: Physiology Authors: Olver, T. D., Hiemstra, J. A., Edwards, J. C., Ferguson, B. S., Laughlin, M. H., Emter, C. A. Tags: RESEARCH ARTICLE Source Type: research

Heart failure with preserved ejection fraction: chronic low-intensity interval exercise training preserves myocardial O2 balance and diastolic function
In conclusion, chronic low-intensity interval exercise training attenuates diastolic impairment by promoting compliant extracellular matrix fibrotic components and preserving extracellular matrix regulatory mechanisms, preserves myocardial oxygen balance, and promotes a physiological molecular hypertrophic signaling phenotype in a large animal model resembling heart failure with preserved ejection fraction.
Source: Journal of Applied Physiology - January 1, 2013 Category: Physiology Authors: Marshall, K. D., Muller, B. N., Krenz, M., Hanft, L. M., McDonald, K. S., Dellsperger, K. C., Emter, C. A. Tags: ARTICLES Source Type: research

Exercise as medicine: Role in the management of primary hypertension
Applied Physiology, Nutrition, and Metabolism, Volume 0, Issue 0, Page 1-3, e-First articles. Primary hypertension affects ∼1 in 5 Canadians and significantly increases the risk of myocardial infarction, stroke, heart failure, and early mortality. Guidelines for the management of hypertension recommend lifestyle modifications (e.g., increased physical activity, smoking cessation, moderate alcohol consumption, improved dietary choices) as the frontline strategy to prevent and manage high blood pressure (BP). In particular, acute and chronic aerobic exercise has consistently been shown to reduce resting and ambulator...
Source: Applied Physiology, Nutrition, and Metabolism - February 12, 2014 Category: Physiology Tags: article Source Type: research

Blood Flow Restriction Exercise Attenuates the Exercise-Induced Endothelial Progenitor Cell Response in Healthy, Young Men
Conclusion In summary, this is the first study to show that BFR exercise did not augment EPC response to exercise, and in fact blunted the EPC response to low load unilateral KE exercise in young, healthy males. Ethics Statement This study was carried out in accordance with the recommendations of Edinburgh Napier University Research and Ethics Governance Committee. The study was ethically approved by Edinburgh Napier University Research and Ethics Governance Committee. All participants gave written informed consent in accordance with the Declaration of Helsinki. Author Contributions MR, RM, AP, CW, GF-J designed the s...
Source: Frontiers in Physiology - April 16, 2019 Category: Physiology Source Type: research