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Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus.
Abstract Patients with type 2 diabetes mellitus (T2DM) exhibit an increased risk for cardiovascular (CV) events. Hyperglycemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little or no impact on reducing CV risk, especially in patients with a long duration of T2DM and prevalent CV disease (CVD). Sodium-glucose cotransporter-2 (SGLT2) inhibitors are the new class of glucose-lowering medications that increase urinary glucose excretion, thus improving glycemic control, independent of insulin. The recently p...
Source: Indian Heart J - November 1, 2018 Category: Cardiology Authors: Pancholia AK Tags: Indian Heart J Source Type: research

Prevalence, risk determinants and consequences of atrial fibrillation in rheumatic heart disease: 6 years hospital based-Himachal Pradesh- Rheumatic Fever/Rheumatic Heart Disease (HP-RF/RHD) Registry.
CONCLUSION: AF is common in RHD patients and is significantly associated with heart failure and systemic thromboembolism. Age, mitral stenosis severity, tricuspid regurgitation and LA size were independently associated with AF. PMID: 30595324 [PubMed - in process]
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Negi PC, Sondhi S, Rana V, Rathoure S, Kumar R, Kolte N, Kumar R, Rao S, Diman A, Mahajan K, Dev M, Kandoria A, Ganju N, Bhardwaj R, Merwaha R, Sharma R, Asotra S Tags: Indian Heart J Source Type: research

Neutrophil-to-lymphocyte ratio predicts heart failure readmissions and outcomes in patients undergoing transcatheter aortic valve replacement.
CONCLUSION: NLR predicts all-cause mortality, MACE, and HF hospitalization 1 year after TAVR. NLR with TAVR risk score improved predictability for MACE. Further studies for prognostication using NLR are warranted. PMID: 30595282 [PubMed - in process]
Source: Indian Heart J - December 1, 2018 Category: Cardiology Authors: Khalil C, Pham M, Sawant AC, Sinibaldi E, Bhardwaj A, Ramanan T, Qureshi R, Khan S, Ibrahim A, Gowda SN, Pomakov A, Sadawarte P, Lahoti A, Hansen R, Baldo S, Colern G, Pershad A, Iyer V Tags: Indian Heart J Source Type: research

Levosimendan for patients with heart failure undergoing major oncological surgery: A randomised blinded pilot study
Conclusion: In patients with low EF <35% and CHF, administration of levosimendan for 24 hours before major abdominal oncologic surgeries may reduce the risk of hypotension and decompensated heart failure and may improve cardiac function.
Source: Indian Journal of Anaesthesia - December 10, 2019 Category: Anesthesiology Authors: Ehab H Shaker Khaled Hussein Ehab M Reyad Source Type: research

Deep learning approach for diabetes prediction using PIMA Indian dataset
ConclusionThe outcome of the study confirms that DL provides the best results with the most promising extracted features. DL achieves the accuracy of 98.07% which can be used for further development of the automatic prognosis tool. The accuracy of the DL approach can further be enhanced by including the omics data for prediction of the onset of the disease.
Source: Journal of Diabetes and Metabolic Disorders - April 13, 2020 Category: Endocrinology Source Type: research

Ethnic differences in atrial fibrillation among patients with heart failure in Asia
ConclusionsAmong patients with HF across Asia, clinical correlates and adverse outcomes associated with AF are similar across ethnicities; however, there are striking ethnic variations in the prevalence of AF that are not accounted for by known risk factors.
Source: ESC Heart Failure - May 7, 2020 Category: Cardiology Authors: Eugene S.J. Tan, Vera Goh, Bernadet T. Santema, Wan Ting Tay, Tiew ‐Hwa Katherine Teng, Jonathan Yap, Jasper Tromp, Chung‐Lieh Hung, Vijay Chopra, Inder Anand, Michael R. MacDonald, Lieng Hsi Ling, ASIAN‐HF investigators, Isabelle C. Va Tags: Original Research Article Source Type: research

What Are the Main Acyanotic Congenital Heart Diseases?
Discussion Congenital heart diseases (CHD) are malformations of the heart and great vessels. It occurs in about 5-8/1000 live births. Cyanotic congenital heart disease is often noted perinatally because of cyanosis, respiratory distress and/or poor feeding or other distress type problems. A review can be found here. Acyanotic congenital heart disease (ACHD) can present at birth but often is seen in older children or adults unless the lesions are severe, especially obstructive lesions. Severe lesions may also cause cyanosis and distress type problems in patients also. Shunting lesions cause problems by diverting blood flo...
Source: PediatricEducation.org - August 17, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Gender differences in the epidemiology of Rheumatic Fever/Rheumatic heart disease (RF/RHD) patient population of hill state of northern India; 9 years prospective hospital based, HP-RHD registry.
CONCLUSIONS: RF/RHD is more prevalent in females. Gender has a significant association with the pattern of valvular involvement. The severity of valvular dysfunction and cardiovascular complications had no significant association with gender. PMID: 33357644 [PubMed - in process]
Source: Indian Heart J - November 1, 2020 Category: Cardiology Authors: Negi PC, Kandoria A, Asotra S, Ganju NK, Merwaha R, Sharma R, Mahajan K, Rao S Tags: Indian Heart J Source Type: research

Gender differences in the epidemiology of Rheumatic Fever/Rheumatic heart disease (RF/RHD) patient population of hill state of northern India; 9 years prospective hospital based, HP-RHD registry
CONCLUSIONS: RF/RHD is more prevalent in females. Gender has a significant association with the pattern of valvular involvement. The severity of valvular dysfunction and cardiovascular complications had no significant association with gender.PMID:33357644 | PMC:PMC7772586 | DOI:10.1016/j.ihj.2020.09.011
Source: Indian Heart J - December 28, 2020 Category: Cardiology Authors: Prakash Chand Negi Arvind Kandoria Sanjeev Asotra Neeraj Kumar Ganju Rajeev Merwaha Rajesh Sharma Kunal Mahajan Shivani Rao Source Type: research

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