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Specialty: Cardiology
Condition: Heart Attack
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Total 78 results found since Jan 2013.
The Impact of Social Determinants of Health and Lifestyle on the Association of Lipoprotein(a) with Myocardial Infarction and Stroke
CONCLUSIONS AND RELEVANCE: SDOH and lifestyle factors were predictors for MI and stroke that did not impact the association between Lp(a) and cardiovascular events. Our findings support that Lp(a) is an independent risk factor for MI and possibly stroke.PMID:37693416 | PMC:PMC10491356 | DOI:10.1101/2023.09.01.23294968
Source: Atherosclerosis - September 11, 2023 Category: Cardiology Authors: Eric J Brandt Matthias Kirch Nimai Patel Chaitanya Chennareddy Venkatesh L Murthy Sascha N Goonewardena Source Type: research
Atherosclerotic Disease: Pathogenesis and Approaches to Management
Med Clin North Am. 2023 Sep;107(5):793-805. doi: 10.1016/j.mcna.2023.04.004. Epub 2023 Jun 1.ABSTRACTAtherosclerotic disease, including stroke and myocardial infarction, is the leading cause of morbidity and mortality worldwide. Atherosclerotic plaque formation occurs in the setting of excess oxidative and hemodynamic stress and is perpetuated by smoking, poor diet, dyslipidemia, hypertension, and diabetes. Plaque may rupture, resulting in acute thrombotic events. Smoking cessation, lifestyle modification, risk factor optimization, and antithrombotic therapies are the mainstays of atherosclerotic disease management and are...
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Amanda M Morrison Alexander E Sullivan Aaron W Aday Source Type: research
DL-3-n-butylphthalide improves the endothelium-dependent vasodilation in high-fat diet-fed ApoE < sup > -/- < /sup > mice via suppressing inflammation, endothelial necroptosis and apoptosis
This study aims to explore whether NBP is able to improve endothelium-dependent vasodilation in atherosclerosis and the underlying mechanisms. Male ApoE-/- mice were fed with a high-fat diet (HFD) for 9-16 weeks to establish a model of atherosclerosis. NBP were given to the mice after eating HFD for 6 weeks and atorvastatin served as a positive control. The endothelium-dependent vasodilation, the blood flow velocity, the atherosclerotic lesion area, the serum levels of lipids, inflammatory cytokines and necroptosis-relevant proteins (RIPK1, RIPK3 and MLKL), and the endothelial necroptosis and apoptosis within the aorta wer...
Source: Atherosclerosis - August 3, 2023 Category: Cardiology Authors: Li-Qun Lu Nian-Sheng Li Ming-Rui Li Jiao-Yang Peng Li-Jing Tang Xiu-Ju Luo Jun Peng Source Type: research
Peripheral artery disease: Update on etiology, pathophysiology, diagnosis and treatment
Med Clin (Barc). 2023 Jul 28:S0025-7753(23)00361-5. doi: 10.1016/j.medcli.2023.06.005. Online ahead of print.ABSTRACTPeripheral artery disease (PAD) is a condition related to atherosclerosis affecting >200 million people worldwide, and it increases cardiovascular morbidity (mainly from myocardial infarction and stroke) and mortality. Indeed, PAD patients are classified as patients at very high cardiovascular risk. The most common manifestation of PAD is intermittent claudication, which is associated with reduced mobility and leg pain. Nevertheless, asymptomatic PAD is the most frequent form of PAD worldwide; therefore, ...
Source: Atherosclerosis - July 30, 2023 Category: Cardiology Authors: Dar ío Mandaglio-Collados Francisco Mar ín Jos é Miguel Rivera-Caravaca Source Type: research
A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice
Front Pharmacol. 2023 May 30;14:1204905. doi: 10.3389/fphar.2023.1204905. eCollection 2023.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial walls that develops at predisposed sites. As a major risk factor for adverse cardiovascular pathology, atherosclerosis can progress to myocardial infarction and stroke, due to the rupture of unstable atherosclerotic lesions. Macrophage uptake of modified lipoproteins and metabolic dysfunction contributes significantly to the initiation and development of atherosclerotic lesions. The cluster of differentiation 36 receptor [CD36 (SR-B2)] plays a key role in ather...
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Jade Gauvin Genevi ève Frégeau Hanan Elimam Liliane M énard David Huynh Catherine L ê Ahsanullah Ahsanullah William D Lubell Huy Ong Sylvie Marleau Source Type: research
Television Viewing Time and All-cause and Cardiovascular Disease Mortality Among Japanese Adults with and without a History of Stroke or Myocardial Infarction
CONCLUSIONS: Prolonged TV viewing time was associated with higher risks of all-cause and CVD mortality in stroke or MI survivors and in persons without a history of them. It may be recommended to reduce sedentary time for stroke or MI survivors, independent of the level of physical activity.PMID:37225520 | DOI:10.5551/jat.63959
Source: Journal of Atherosclerosis and Thrombosis - May 24, 2023 Category: Cardiology Authors: Masayuki Teramoto Kazumasa Yamagishi Kokoro Shirai Isao Muraki Shigekazu Ukawa Akiko Tamakoshi Hiroyasu Iso Source Type: research
Deficiency of germinal center kinase TRAF2 and NCK-interacting kinase (TNIK) in B cells does not affect atherosclerosis
CONCLUSION: We here conclude that in hyperlipidemic ApoE-/- mice, B cell specific TNIK deficiency does not affect atherosclerosis.PMID:37215541 | PMC:PMC10196212 | DOI:10.3389/fcvm.2023.1171764
Source: Atherosclerosis - May 22, 2023 Category: Cardiology Authors: Bram W van Os Pascal J H Kusters Myrthe den Toom Linda Beckers Claudia M van Tiel Winnie G Vos Elize de Jong Arnd Kieser Cindy van Roomen Christoph J Binder Myrthe E Reiche Menno P de Winther Laura A Bosmans Esther Lutgens Source Type: research
Evaluation of anti-atherosclerotic effects of Sitagliptin via modulation of the mTOR pathway in male rabbits
This study aimed to investigate the effect of Sitagliptin on the progression of atherosclerosis. Twenty-one male New Zealand White rabbits weighing 2-2.5 kg each were split into three groups: normal control, atherogenic control, and Sitagliptin-treated. The following parameters: serum triglycerides (TG), total cholesterol (TC), LDL, and a tissue autophagy marker (p62) using ELISA, aortic mRNA expression of mTORC1 marker using Real-Time Quantitative PCR(RT-qPCR), and histological inspection of the aorta were assessed. The mRNA expression of mTORC1 and the lipid profile of aortic tissue are considerably elevated in atherogen...
Source: Atherosclerosis - May 11, 2023 Category: Cardiology Authors: Hussam Hamza Sahib Bassim Mohammad Najah Rayish Hadi Source Type: research
Heterozygosity for ADP-ribosylation factor 6 suppresses the burden and severity of atherosclerosis
PLoS One. 2023 May 10;18(5):e0285253. doi: 10.1371/journal.pone.0285253. eCollection 2023.ABSTRACTAtherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) is a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability and is sensitive to changes in shear stress. Here, using atheroprone, ApoE-/- mice, with a single allele deletion of Arf6 (HET) or wildtype Arf6 (WT), we demonstrate that reduction in Arf6 attenuates atherosclerotic plaque burden and severity. We found that plaque burden in the descending...
Source: Atherosclerosis - May 10, 2023 Category: Cardiology Authors: Venkateswara R Gogulamudi Md Torikul Islam Jessica R Durrant Adelola O Adeyemo Daniel W Trott Mi Ho Hyuhn Weiquan Zhu Anthony J Donato Ashley E Walker Lisa A Lesniewski Source Type: research
Research on Hepatocyte Regulation of PCSK9-LDLR and Its Related Drug Targets
Chin J Integr Med. 2023 Mar 13. doi: 10.1007/s11655-023-3545-z. Online ahead of print.ABSTRACTThe prevalence of hyperlipidemia has increased significantly due to genetic, dietary, nutritional and pharmacological factors, and has become one of the most common pathological conditions in humans. Hyperlipidemia can lead to a range of diseases such as atherosclerosis, stroke, coronary heart disease, myocardial infarction, diabetes, and kidney failure, etc. High circulating low-density lipoprotein cholesterol (LDL-C) is one of the causes of hyperlipidemia. LDL-C in the blood binds to LDL receptor (LDLR) and regulates cholesterol...
Source: Atherosclerosis - March 13, 2023 Category: Cardiology Authors: Su-Su Liu Tong Yu Yan-Fang Qiao Shu-Xiao Gu Xin-Lou Chai Source Type: research
