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Source: Atherosclerosis
Condition: Heart Attack
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Total 99 results found since Jan 2013.
CD137: A checkpoint regulator involved in atherosclerosis
Inflammation is associated with atherosclerotic plaque development and precipitation of myocardial infarction and stroke, and anti-inflammatory therapy may reduce disease severity. Costimulatory molecules are key regulators of immune cell activity and inflammation, and are associated with disease development in atherosclerosis. Accumulating evidence indicates that a costimulatory molecule of the Tumor Necrosis Factor Receptor Superfamily, the checkpoint regulator CD137, promotes atherosclerosis and vascular inflammation in experimental models.
Source: Atherosclerosis - March 5, 2018 Category: Cardiology Authors: Leif Å. Söderström, Laura Tarnawski, Peder S. Olofsson Tags: Review article Source Type: research
Stroke outcome is associated with baseline renal function: A risk factor that matters!
Kidney disease and more specifically chronic kidney disease (CKD) prevalence is on the rise and it is estimated that the prevalence of CKD is almost 11 –13% in the world [1]. During the last twenty years, a number of studies have shown that patients with CKD have a higher risk for cardiovascular events including stroke and myocardial infarction [2–5]. Furthermore, CKD has been associated with an increased risk for all mortality and cardiovascul ar (CV) mortality [6]. In light of this, it is not surprising that in this issue of Atherosclerosis Wang et al.
Source: Atherosclerosis - January 12, 2018 Category: Cardiology Authors: Joy Roy Tags: Editorial Source Type: research
Relationship between thrombus age in aspirated coronary material and mid-term major adverse cardiac and cerebrovascular events in patients with acute myocardial infarction
Recent studies have shown that coronary thrombus histopathology is associated with impaired myocardial reperfusion and poor clinical outcome in patients with acute myocardial infarction (AMI). We sought to investigate the age of thrombi aspirated during percutaneous coronary intervention (PCI) in patients with AMI and evaluate the relationship between histopathologic findings and major adverse cardiac and cerebrovascular events (MACCEs) defined as all-cause death, stroke, or myocardial infarction within 6 months of PCI.
Source: Atherosclerosis - December 2, 2017 Category: Cardiology Authors: Kensaku Nishihira, Yoshisato Shibata, Atsushi Yamashita, Nehiro Kuriyama, Yujiro Asada Source Type: research
GLP-1 receptor agonists: An example of the challenge for animal models to predict plaque instability/rupture and cardiovascular outcomes
Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder characterized by hyperglycaemia and insulin resistance. Diabetes mellitus is well-established as a major risk factor for the development of cardiovascular disease (CVD). A collaborative meta-analysis of 102 prospective studies revealed that people with diabetes are exposed to two-fold excess risk for coronary heart disease and stroke after adjustment for lipid profiles and inflammatory markers [1]. Moreover, prevention of cardiovascular complications is regularly integrated in the regime of medical care in diabetic patients, as these patients have a similar ri...
Source: Atherosclerosis - August 18, 2017 Category: Cardiology Authors: Ya-Lan Ying, Yung-Chih Chen, Karin Jandeleit-Dahm, Karlheinz Peter Tags: Editorial Source Type: research
Inertial cavitation effect of catheter- based Q-switched ND:YAG laser enhance extracorporeal pulsed- focused ultrasound thrombolysis
Aim: A plaque may rupture with high risk of subsequent thrombus- mediated acute clinical events such as myocardial infarction and stroke. Catheter-based lasers have been extensively studied as an effective method to treat thrombosis. Focused ultrasound is one of the non- invasive methods to treat abnormal tissues. In pulsed- focused ultrasound with low duty cycle, which is used for thrombolysis, energy deposition rates are low enough that temperature rises are well below the threshold for thermal damage.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Hossein Mehrad, Mehdi Farhoudi, Alireza Paknezhad Source Type: research
Clinical case of hyperlipidemia type IV in a man with diabetes, myocardial infarction and stroke
Aim: Hypercholesterolemia is one of the main risk factors of atherosclerosis development. Lipid disorders occur as a result of some genetic abnormalities or secondary to underlying disease, for example, diabetes mellitus. Insulin resistance in such patient is often the reason of hypertriglyceridemia and low serum high-density lipoprotein cholesterol concentrations. Hypertriglyceridemia is the most common lipid abnormality in young patients with myocardial infarction.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Olga Baturina, Olga Mironova Source Type: research
Relationship of platelet thromboxane inhibition by aspirin and all-cause mortality in patients with stable coronary artery disease
Aim: Anti-platelet therapy with aspirin (ASA) reduces nonfatal myocardial infarction, stroke, and cardiovascular death by irreversibly inhibiting platelet COX-1 and TxA2 production. However, variable TxA2 inhibition is common. We studied the relationship of urinary 11dhTxB2, an inactive TxA2 metabolite, with all-cause mortality in stable coronary artery disease (CAD) patients on ASA treatment.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Luis R. Lopez, Anupama Vasudevan, Mohanakrishnan Sathyamoorthy, Jeffrey M. Schussler, Carlos Velasco, Caren Swift, Raphael Schiffmann, Teodoro Boittiglieri, Peter A. McCullough Source Type: research
Intraindividual variability of lipoprotein(a) and implications for the decision-making process for lipoprotein(a) lowering therapy
Aim: Lipoprotein (a) is an independent risk factor for myocardial infarction, stroke and calcific aortic valve stenosis. Circulating Lp(a) levels are largely genetically determined by SNP and a wide heterogeneity in kringle IV type 2 repeats. Furthermore, significant racial differences exist. Lifestyle modifications like nutrition and sports have no or less effect on Lp(a) serum levels.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Michael Marcus Hoffmann, Lisa Sch äfer, Karl Winkler, Brigitte König Source Type: research
PET-CT imaging of atherosclerosis in Ldlr-/- mice treated with an anti-LDL(-) nanoformulation
Aim: Atherosclerosis is a chronic inflammatory disease underlying the myocardial infarction and ischemic stroke. The electronegative low-density lipoprotein (LDL-), an in vivo modified subfraction of LDL, is pro-inflammatory and plays a key role in atherosclerosis contributing to foam cells formation. In the nanotechnology field, some strategies have emerged such as the use of nano-carriers with synthetic polymer nanoparticles and nanoparticle-protein conjugates as promising approaches for the prevention and treatment of diseases.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Dulcineia Abdalla, Marcela Cavalcante, Walter Turato, Soraya Kazuma, Marcia Adorne, Silvia Guterres, Adriana Pohlmann Source Type: research
Screening for unknown hypercholesterolemia in a hospital population: A model for preventive medicine
Aim: The autosomal dominant hypercholesterolemia (ADH) is one of the most frequent monogenic diseases and it ’s strongly related to cardiovascular disease (myocardial infarction, stroke).Genes classically associated with ADH are LDL receptor gene (Familial hypercholesterolemia or FH), Apo B gene (Familial Detective ApoB or FDB) and PCSK9 (FH3). The frequency of heterozygous FH is estimated to be approxim ately 1/200 - 1/500 in general population; so, this disease is one of the most common monogenic syndromes.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Roberto Scicali, Roberta Platania, Giacomo Purrazzo, Alberto Giannone, Viviana Ferrara, Francesca Urbano, Agnese Filippello, Salvo Piro, Maria Agata Rabuazzo, Emanuele Farrugia, Venerando Rapisarda, Francesco Purrello Source Type: research
Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
In this study we investigate whether TLR7 expression levels in the atherosclerotic lesion are correlated to patient outcome.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Glykeria Karadimou, Lasse Folkersen, Martin Berg, Ljubica Perisic, Andrea Discacciati, Joy Roy, G öran K. Hansson, Jonas Persson, Gabrielle Paulsson-Berne Source Type: research
Secretory phospholipase A2 modified high-density lipoprotein potently suppresses platelet activation
Aim: Levels of secretory phospholipases A2 (sPLA2) highly increase under acute and chronic inflammatory conditions. sPLA2 is mainly associated with high-density lipoproteins (HDL) and generates bioactive lysophospholipids implicated in acute and chronic inflammatory processes. Unexpectedly, pharmacological inhibition of sPLA2 in patients with acute coronary syndrome was associated with an increased risk of myocardial infarction and stroke. Given that platelets are key players in thrombosis and inflammation, we hypothesized that sPLA2-induced hydrolysis of HDL-associated phospholipids (sPLA2-HDL) generates modified HDL part...
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Gunther Marsche, Michael Holzer, Sanja Curcic Source Type: research
Oral health and cardiovascular disease risk in a cohort of periodontitis patients
The aim of this study was to determine whether oral health is uniformly associated with three different cardiovascular diseases (CVDs), including myocardial infarction (MI), stroke, and heart failure (HF), which has not been studied previously.
Source: Atherosclerosis - May 11, 2017 Category: Cardiology Authors: Anders Holmlund, Erik Lampa, Lars Lind Source Type: research
Reply to: “Endothelial progenitor cell release is usually considered a beneficial effect: Problems in interpreting the acute effects of e-cigarette use”
Vascular injury has long been known to be the main cause for mobilization of endothelial progenitor cells (EPCs) [1 –3]. It has been proven that the strongest factor mobilizing EPCs is hypoxia in the vascular wall, causing the release of vascular endothelial growth factor 2 (VEGF-2) and stromal derived factor 1 (SDF-1) [1–3]. These two factors bind to receptors on EPCs, initiating mobilization and homing to t he site of lesion. Therefore, it is not surprising that in cases of obvious vascular damage, such as in myocardial infarction or stroke, EPCs are highly elevated [1–3].
Source: Atherosclerosis - January 19, 2017 Category: Cardiology Authors: Lukasz Antoniewicz, Anna Kiessling, Fariborz Mobarrez, Magnus Lundb äck Tags: Correspondence Source Type: research
