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Changing Trends of Atherosclerotic Risk Factors Among Patients with Acute Myocardial Infarction and Acute Ischemic Stroke
We aimed to evaluate the secular trends in demographics, risk factors as well as clinical characteristics of patients presenting with acute myocardial infarction (AMI) or acute ischemic stroke (AIS), using a large nationally representative dataset of in-hospital admissions. We used the 2003-2013 Nationwide Inpatient Sample. All admissions with primary diagnosis of AMI or AIS were included. Across 2003-2013, a total of 1,360,660 patients with AMI and 937,425 patients with AIS were included in the study.
Source: The American Journal of Cardiology - February 27, 2017 Category: Cardiology Authors: Shikhar Agarwal, Karan Sud, Badal Thakkar, Venu Menon, Wael A. Jaber, Samir R. Kapadia Source Type: research

Prevalence and Determinants of Atrial Fibrillation-associated In-hospital Ischemic Stroke in patients with Acute Myocardial Infarction undergoing Percutaneous Coronary Intervention
Atrial Fibrillation (AF) is an established risk factor ischemic stroke (IS) and is commonly encountered in patient hospitalized with acute myocardial infarction (AMI). Uncommonly, IS can occur as a complication resulting from percutaneous coronary intervention (PCI). There is limited real world data regarding AF-associated in-hospital IS (IH-IS) in patients admitted with AMI undergoing PCI. We queried the National Inpatient Sample database from January 2010 to December 2014 to identify patients admitted with AMI who underwent PCI.
Source: The American Journal of Cardiology - December 29, 2020 Category: Cardiology Authors: Shivaraj Patil, Karthik Gonuguntla, Chaitanya Rojulpote, Manish Kumar, Srinivas Nadadur, Robert J. Nardino, Christopher Pickett Source Type: research

Comparison of In-Hospital Outcomes With Low-Dose Fibrinolytic Therapy Followed by Urgent Percutaneous Coronary Intervention Versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction
In patients with acute ST-elevation myocardial infarction (STEMI), a strategy of prehospital reduced dose fibrinolytic administration coupled with urgent percutaneous coronary intervention (PCI), termed FAST-PCI strategy, has been found to be superior to primary PCI (PPCI) alone. A coordinated STEMI system of care that includes FAST-PCI should offer better outcomes than a system in which prehospital diagnosis of STEMI is followed by PPCI alone. The aim of this study was to compare the in-hospital outcomes for patients treated with the FAST-PCI approach with outcomes for patients treated with the PPCI approach in a common s...
Source: The American Journal of Cardiology - March 14, 2013 Category: Cardiology Authors: Neel S. Bhatt, Amirreza Solhpour, Prakash Balan, Armin Barekatain, James J. McCarthy, Stefano Sdringola, Ali E. Denktas, Richard W. Smalling, H. Vernon Anderson Tags: Coronary Artery Disease Source Type: research

30-Year Trends in Patient Characteristics, Treatment Practices, and Long-Term Outcomes of Adults Aged 35 to 54 Years Hospitalized With Acute Myocardial Infarction
The objectives of our population-based study were to describe>3-decade-long trends in the clinical features, treatment practices, and long-term outcomes of young adults aged 35 to 54 years discharged from the hospital after AMI. The study population consisted of 2,142 residents of the Worcester (Massachusetts) metropolitan area who were hospitalized with AMI at all central Massachusetts medical centers during 16 annual periods from 1975 to 2007. Our primarily male study population had an average age of 47 years. Patients hospitalized during the most recent decade (1997 to 2007) under study were more likely to have a hist...
Source: The American Journal of Cardiology - January 15, 2014 Category: Cardiology Authors: Mayra Tisminetzky, David D. McManus, Joel M. Gore, Jorge Yarzebski, Andrew Coles, Darleen Lessard, Robert J. Goldberg Tags: Coronary Artery Disease Source Type: research

Association of Frailty Status on the Causes and Outcomes of Patients Admitted With Cardiovascular Disease
Data are limited about the contemporary association between frailty and the causes and outcomes of patients admitted with cardiovascular diseases (CVD). Using the US National Inpatient Sample, CVD admissions of interest (acute myocardial infarction, ischemic stroke, atrial fibrillation (AF), heart failure, pulmonary embolism, cardiac arrest, and hemorrhagic stroke) were stratified by Hospital Frailty Risk Score (HFRS). Logistic regression was used to determine adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of in-hospital mortality among different groups with frailty.
Source: The American Journal of Cardiology - January 24, 2023 Category: Cardiology Authors: Balamrit Singh Sokhal, Andrija Mateti ć, Muhammad Rashid, Jo Protheroe, Richard Partington, Christian Mallen, Mamas A. Mamas Source Type: research

Comparison of Procedural Success and Long-Term Outcomes of Stent Thrombosis in Coronary Bypass Grafts Versus Native Coronary Arteries
Percutaneous coronary intervention within bypass grafts accounts for a significant percentage of total interventions. Bypass graft interventions are associated with an increased risk for stent thrombosis (ST), a condition that leads to significant morbidity and mortality. Despite this, the procedural characteristics and long-term outcomes of patients with bypass-graft ST have not been reported. The aim of the present study was to evaluate the procedural success and long-term outcomes of patients presenting with ST of coronary bypass grafts. Clinical and procedural characteristics of 205 ST cases at 5 academic hospitals wer...
Source: The American Journal of Cardiology - December 20, 2012 Category: Cardiology Authors: Stephen W. Waldo, Ehrin J. Armstrong, Khung Keong Yeo, Ehtisham Mahmud, Mitul Patel, Ryan Reeves, John S. MacGregor, Reginald I. Low, Jason H. Rogers, Kendrick A. Shunk Tags: Coronary Artery Disease Source Type: research

Comparison of Outcomes for Patients ≥75 Years of Age Treated With Pre-Hospital Reduced-Dose Fibrinolysis Followed by Percutaneous Coronary Intervention Versus Percutaneous Coronary Intervention Alone for Treatment of ST-Elevation Myocardial Infarction
A coordinated system of care for patients with ST-segment elevation myocardial infarctions that includes prehospital administration of reduced-dose fibrinolytic agents coupled with urgent percutaneous coronary intervention (PCI), termed FAST-PCI, has been shown to be at least as effective as primary PCI (PPCI) alone. However, this reduced-dose fibrinolytic strategy could be associated with increased bleeding risk, especially in elderly patients. The purpose of this study was to examine 30-day outcomes in patients aged ≥75 years with ST-segment elevation myocardial infarctions treated with either strategy. Data from 120 p...
Source: The American Journal of Cardiology - October 28, 2013 Category: Cardiology Authors: Amirreza Solhpour, Kay-Won Chang, Prakash Balan, Chunyan Cai, Stefano Sdringola, Ali E. Denktas, Richard W. Smalling, H. Vernon Anderson Tags: Coronary Artery Disease Source Type: research

Effect of an Invasive Strategy on Outcome in Patients ≥75 Years of Age with Non-ST-Elevation Acute Coronary Syndrome
The Italian Elderly ACS study was the first randomized trial (RCT) comparing an early aggressive (EA) with an initially conservative strategy in patients with NSTEACS aged ≥75 years, with the results showing no significant benefit of EA. We evaluated the outcomes of study patients, according to the treatment actually received during hospitalization. The RCT enrolled 313 patients. The primary endpoint was the composite of death, myocardial infarction (MI), disabling stroke, and repeat hospital stay for cardiovascular causes or bleeding within 1 year.
Source: The American Journal of Cardiology - December 17, 2014 Category: Cardiology Authors: Gennaro Galasso, Stefano De Servi, Stefano Savonitto, Teresa Strisciuglio, Raffaele Piccolo, Nuccia Morici, Ernesto Murena, Claudio Cavallini, Anna Sonia Petronio, Federico Piscione Source Type: research

Relation Of Cardiac Complications In The Early Phase Of Community-Acquired Pneumonia To Long-Term Mortality And Cardiovascular Events
Community-acquired pneumonia (CAP) is complicated by cardiac events in the early phase of the disease. Aim of this study was to assess if these intra-hospital cardiac complications may account for overall mortality and cardiovascular events occurring during a long-term follow up. Three hundred and one consecutive patients admitted to the University-Hospital, Policlinico Umberto I, with CAP were prospectively recruited and followed-up for a median of 17.4 months). Primary end-point was the occurrence of death for any cause and secondary endpoint was the occurrence of cardiovascular events (cardiovascular death, non-fatal my...
Source: The American Journal of Cardiology - May 21, 2015 Category: Cardiology Authors: Roberto Cangemi, Camilla Calvieri, Marco Falcone, Tommaso Bucci, Giuliano Bertazzoni, Maria Gabriella Scarpellini, Francesco Barillà, Gloria Taliani, Francesco Violi, in collaboration with the SIXTUS study group Source Type: research

Cardiac Complications after Community-acquired Pneumonia
We read with interest the article by Cangemi et al “Relation of cardiac complications in the early phase of community –acquired pneumonia to long-term mortality and cardiovascular events”1 published in the August 5th issue of The American Journal of Cardiology. The authors show that 18% of patients with community-acquired pneumonia (CAP) study develop intra-hospital cardiac complications, defined as myocardial infarction (MI) and atrial fibrillation. Furthermore, the authors prospectively show that these cardiac complications in the early phase of CAP are associated with adverse long-term cardiovascular prognosis (wi...
Source: The American Journal of Cardiology - October 15, 2015 Category: Cardiology Authors: Carlos G. Santos-Gallego, Juan Badimon Source Type: research

Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (From a Danish Nationwide Cohort Study)
Periodontitis and atherosclerosis are highly prevalent chronic inflammatory diseases and it has been suggested that periodontitis is an independent risk factor of cardiovascular disease (CVD) and that a causal link may exist between the two diseases. Using Danish national registers we identified a nationwide cohort of 17,691 patients who received a hospital diagnosis of periodontitis within a 15 year period and matched them with 83,003 controls from the general population. We performed Poisson regression analysis to determine crude and adjusted incidence rate ratios (IRRs) of myocardial infarction, ischemic stroke, cardiov...
Source: The American Journal of Cardiology - May 30, 2016 Category: Cardiology Authors: Gorm Mørk Hansen, Alexander Egeberg, Palle Holmstrup, Peter Riis Hansen Source Type: research

Relation of Periodontitis to Risk of Cardiovascular and All-Cause Mortality (from a Danish Nationwide Cohort Study)
Periodontitis and atherosclerosis are highly prevalent chronic inflammatory diseases, and it has been suggested that periodontitis is an independent risk factor of cardiovascular disease (CVD) and that a causal link may exist between the 2 diseases. Using Danish national registers, we identified a nationwide cohort of 17,691 patients who received a hospital diagnosis of periodontitis within a 15-year period and matched them with 83,003 controls from the general population. We performed Poisson regression analysis to determine crude and adjusted incidence rate ratios of myocardial infarction, ischemic stroke, cardiovascular...
Source: The American Journal of Cardiology - May 30, 2016 Category: Cardiology Authors: Gorm M ørk Hansen, Alexander Egeberg, Palle Holmstrup, Peter Riis Hansen Tags: Preventive Cardiology Source Type: research

Temporal-Trends in Sex-Related Differences and Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation (From the Israeli TAVI Multicentre Registry)
We evaluated temporal trends in sex-related differences in patients undergoing trans-catheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis (AS) from a multicentre TAVI registry during the years 2008-2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1.2, 4.4) years. For temporal trends analysis, the entire population was divided according to period of procedure: 2008-2012 and 2013-2016. During the 2008-2012 period, the rates of in-hospital aortic paravalvular leak, myocardial infarction, pacemaker implantation, and stroke were higher among males tha...
Source: The American Journal of Cardiology - October 3, 2018 Category: Cardiology Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ariel Finkelstein, Israel Barbash, Haim Danenberg, Amit Segev, Victor Guetta, Amir Halkin, Hana Vaknin, David Planer, Abid Assali, Alon Barsheshet, Katia Orvin Source Type: research

Temporal Trends in Gender-Related Differences and Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the Israeli Transcatheter Aortic Valve Implantation Multicenter Registry)
We evaluated temporal trends in gender-related differences in patients who underwent transcatheter aortic valve implantation (TAVI) for severe symptomatic aortic stenosis from a multicenter TAVI registry during the years 2008 to 2016. Our final cohort included 1,159 males and 1,370 females, with a median follow-up of 2.3 (IQR 1.2, 4.4) years. For temporal trends analysis, the entire population was divided according to period of procedure: 2008 to 2012 and 2013 to 2016. During the 2008 to 2012 period, the rates of in-hospital aortic paravalvular leak, myocardial infarction, pacemaker implantation, and stroke were higher amo...
Source: The American Journal of Cardiology - October 3, 2018 Category: Cardiology Authors: Osnat Itzhaki Ben Zadok, Ran Kornowski, Ariel Finkelstein, Israel Barbash, Haim Danenberg, Amit Segev, Victor Guetta, Amir Halkin, Hana Vaknin, David Planer, Abid Assali, Alon Barsheshet, Katia Orvin Source Type: research

Comparison of In-hospital Outcomes of Patients With-vs-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
The objective of this study was to evaluate the impact of heart failure (HF) etiology (ischemic cardiomyopathy (IC) vs. non-ischemic cardiomyopathy (NIC)) on in-hospital outcomes in patients undergoing left ventricular assist device (LVAD) placement using the Nationwide Inpatient Sample (NIS) database. We identified patients who underwent LVAD placement from 2011 to 2014. The primary endpoint was the effect of ICM on in-hospital mortality. Secondary endpoints included peri-procedural vascular complications requiring surgery, post-operative myocardial infarction, stroke and hemorrhage requiring transfusion.
Source: The American Journal of Cardiology - November 20, 2018 Category: Cardiology Authors: Hossam Abubakar, Ahmed Subahi, Oluwole Adegbala, Ahmed S Yassin, Emmanuel Akintoye, Ahmed Abdulrahman, Abdelrahman Ahmed, Adedotun Alade, Mohit Pahuja, Luis Afonso Source Type: research

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