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Decreased CSF Levels of ß-Amyloid in Patients With Cortical Superficial Siderosis
Conclusions: Our results demonstrate that the presence and extent of cSS are associated with reduced CSF ß-amyloid 42 levels. Further studies are needed to investigate the underlying mechanisms of this association. Introduction Cerebral amyloid angiopathy (CAA)—characterized by the deposition of ß-amyloid in the walls of leptomeningeal vessels—is a common cerebral small vessel disease and a major cause of intracerebral hemorrhage in the elderly (1–3). Furthermore, it has become evident that CAA is associated with cognitive impairment (4). Specifically, it has been shown that ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Intrathecal Clonidine via Lumbar Puncture Decreases Blood Pressure in Patients With Poorly Controlled Hypertension
ConclusionsThis is the first clinical study in subjects with hypertension that demonstrates significant and profound acute reductions in blood pressure after a single dose of intrathecal clonidine. Future placebo‐controlled, dose‐escalating studies are warranted to assess the long‐term effects of intrathecal clonidine infusion via an implantable drug pump in patients with treatment‐resistant hypertension at risk of stroke or myocardial infarction.
Source: Neuromodulation: Technology at the Neural Interface - April 1, 2015 Category: Biotechnology Authors: Chris B. Komanski, Richard L. Rauck, James M. North, Kyung S. Hong, Robert D'Angelo, Keith R. Hildebrand Tags: Clinical Research Source Type: research