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Stroke paradox with SGLT-2 inhibitors: a play of chance or a viscosity-mediated reality?
Diabetes mellitus is a major risk factor for cardiovascular morbidity and mortality. Current therapeutic strategies have not provided constant beneficial cardiovascular-related results. Sodium–glucose co-transporters 2 (SGLT-2) inhibitors have emerged as a novel antidiabetic class of drugs that exert favourable results in a variety of other cardiovascular risk factors too, such as increased blood pressure and body weight. The Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG OUTCOME) study was the first trial that evaluated cardiovascular outcomes in patients with diabetes with the us...
Source: Journal of Neurology, Neurosurgery and Psychiatry - February 16, 2017 Category: Neurosurgery Authors: Imprialos, K. P., Boutari, C., Stavropoulos, K., Doumas, M., Karagiannis, A. I. Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Risk of stroke in multiple sclerosis and neuromyelitis optic spectrum disorder: a Nationwide cohort study in South Korea
Conclusions The risk of stroke is increased in patients with MS and NMOSD and seemed comparable between the two conditions. This is the first study that estimates the risk of stroke in patients with MS and NMOSD within the same population.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 14, 2022 Category: Neurosurgery Authors: Cho, E. B., Yeo, Y., Jung, J. H., Jeong, S.-M., Han, K.-d., Shin, D. W., Min, J.-H. Tags: Multiple sclerosis Source Type: research

The association of vertebrobasilar calcification with etiological subtypes, stroke recurrence and outcome in acute brainstem ischemic stroke
Publication date: March 2018Source: Neurologia i Neurochirurgia Polska, Volume 52, Issue 2Author(s): Elif Gökçal, Elvin Niftaliyev, Tuğçe Özdemir, Mehmet Kolukısa, Talip AsilAbstractArterial calcification (AC), a frequent finding on imaging studies, has been reported as a risk factor for ischemic stroke. However few studies have explored the association of AC with etiological subtypes and prognostic implications. The purpose of this study was to investigate the association of AC with demograhics, risk factors and etiological subtypes and to determine whether it predicts stroke recurrence and functional outcome in pat...
Source: Polish Journal of Neurology and Neurosurgery - July 6, 2018 Category: Neurosurgery Source Type: research

Which risk factors are more associated with ischemic rather than hemorrhagic stroke in black Africans?
Conclusions: With increasing proportion of the population over 61 years and better BP control, the proportion of IS is expected to rise in black African countries currently undergoing epidemiological transition (changing lifestyle/disease pattern). Therefore, relevant components of the stroke intervention quadrangle (stroke surveillance, acute care, preventive and rehabilitation services) should be tailored toward this need.
Source: Clinical Neurology and Neurosurgery - August 5, 2013 Category: Neurosurgery Authors: Mayowa O. Owolabi, Atinuke M. Agunloye Tags: Original articles Source Type: research

P-008 Evaluating Racial/Ethnic Disparity in Endovascular Thrombectomy Outcome for Acute Stroke Patients: 4,763 patients using Premier data 2011 to 2015
ConclusionsThere were no differences in hospital outcome among races/ethnicities in endovascular thrombectomy outcomes for acute stroke patients in the Premier data. Racial/ethnic disparities play role for patients’ selection not for patients’ outcome in endovascular thrombectomy.DisclosuresS. Park: None. M. Pilot: None. M. Alexander: 1; C; Consultant for Stryker Neurovascular, Medtronic, and Penumbra, Inc. A. Rosengart: None.
Source: Journal of NeuroInterventional Surgery - July 28, 2016 Category: Neurosurgery Authors: Park, S., Pilot, M., Alexander, M., Rosengart, A. Tags: Oral poster abstracts Source Type: research

033 GLP-1RAs reduce stroke incidence in patients with type 2 diabetes mellitus: a meta-analysis
Conclusions This data supports the value of GLP-1RAs in reducing stroke incidence in patients with T2DM. There is potential value in prospective, randomised controlled trials adequately powered to establish the value of GLP-1RAs in stroke prevention in T2DM patients. mark.maskery@doctors.org.uk|ABN Bursary
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 27, 2022 Category: Neurosurgery Authors: Maskery, M., Wall, J., Holscher, C., Jones, S., Price, C., Strain, D., Watkins, C., Werring, D., Emsley, H. Tags: Live Poster, 6 May SIG4: Movement Disorders Source Type: research

Brain natriuretic peptide level on admission predicts recurrent stroke after discharge in stroke survivors with atrial fibrillation
Previous reports indicate that approximately 5–10% of patients with ischemic stroke in Japan experience a stroke recurrence within the first year [1,2]. Recurrent stroke results in further disabilities. Therefore, it is important to identify risk factors associated with recurrent stroke. Several factors have been shown to be associated with recurrent stroke including large artery atherosclerosis [3], diabetes mellitus [3], previous transient ischemic attack (TIA) [3], atrial fibrillation (AF) [3], hypertension [3], increasing age [3], fibrinogen levels [4,5], D-dimer levels [5], and C-reactive protein levels [6].
Source: Clinical Neurology and Neurosurgery - October 3, 2014 Category: Neurosurgery Authors: Kensaku Shibazaki, Kazumi Kimura, Junya Aoki, Kenichiro Sakai, Naoki Saji, Junichi Uemura Source Type: research

O-032 Predictors of Poor Outcomes Despite Successful Recanalization in Patients with Acute Ischemic Stroke
Conclusions Age, occlusion site, high NIHSS, diabetes, not receiving IVtPA, use of rescue therapy and three or more passes, were associated with poor 90-day outcome despite successful recanalization. Disclosures I. Linfante: None. G. Dabus: None. A. Starosciak: None. A. Castonguay: None. R. Gupta: None. C. Sun: None. C. Martin: None. W. Holloway: None. N. Mueller-Kronast: None. J. English: None. T. Malisch: None. F. Marden: None. H. Bozorgchami: None. A. Xavier: None. A. Rai: None. M. Froehler: None. A. Badruddin: None. T. Nguyen: None. M. Taqi: None. M. Abraham: None. V. Janardhan: None. H. Shaltoni: None. R. Novakovic: ...
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Linfante, I., Dabus, G., Starosciak, A., Castonguay, A., Gupta, R., Sun, C., Martin, C., Holloway, W., Mueller-Kronast, N., English, J., Malisch, T., Marden, F., Bozorgchami, H., Xavier, A., Rai, A., Froehler, M., Badruddin, A., Nguyen, T., Taqi, M., Abra Tags: Oral abstracts Source Type: research

Effect of comorbidities on ischemic stroke mortality: An analysis of the National Inpatient Sample (NIS) Database
CONCLUSION: Patients hospitalized from ischemic stroke suffered from the coexistence of other comorbidities. Of the comorbidities studied, IHD was identified as having the most significant impact on in-hospital mortality.PMID:34221599 | PMC:PMC8247684 | DOI:10.25259/SNI_415_2021
Source: Surgical Neurology International - July 5, 2021 Category: Neurosurgery Authors: Frank De Stefano Timothy Mayo Claudia Covarrubias Brian Fiani Brian Musch Source Type: research

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