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Specialty: Molecular Biology
Condition: Mitochondrial Disease
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Total 1057 results found since Jan 2013.
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Chem Biol Interact. 2023 Sep 16:110716. doi: 10.1016/j.cbi.2023.110716. Online ahead of print.ABSTRACTCongenital toxoplasmosis, caused by the opportunistic protozoan parasite T. gondii, can cause stillbirths, miscarriages and fetal abnormalities, as well as encephalitis and chorioretinitis in newborns. Available treatment options rely on antiparasitic drugs that have been linked to serious side effects, high toxicity and the development of drug-resistant parasites. The search for alternative therapeutics to treat this disease without acute toxicity for the mother and child is essential for the advancement of current therap...
Source: Chemico-Biological Interactions - September 18, 2023 Category: Molecular Biology Authors: Samuel Cota Teixeira Marina Paschoalino Guilherme de Souza Alessandra Monteiro Rosini Joed Pires de Lima Junior Luana Carvalho Luz Aryani Felixa Fajardo Mart ínez Rosiane Nascimento Alves Marcos Paulo Oliveira Almeida Jaqueline Lopes Damasceno Marcelo Jo Source Type: research
The Role of Parkin in Rat Pancreatic Beta Cells Fate
In this study, we investigated whether Parkin affects cell viability and ER stress responses under lipotoxic conditions in INS-1E cells. Our results may suggest that silencing Parkin may affect autophagy in addition to apoptosis. We also showed that Parkin may have a protective effect against lipo-toxic effects in INS-1E cells. Consistent with previous studies, we observed that stress responses were different for high and low palmitic acid doses. The Parkin being inhibited under high-dose PA treatment and active under low-dose PA treatment indicate that regulation of stress responses is controlled by environmental conditio...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Hasibe Verdi Hatice Pinar Baysan Cebi Yaprak Yilmaz Yalcin Tulin Ozkan Mehtap Akcil Ok Asuman Sunguroglu Fatma Belgin Atac Source Type: research
GSK-3 α aggravates inflammation, metabolic derangement, and cardiac injury post-ischemia/reperfusion
J Mol Med (Berl). 2023 Sep 14. doi: 10.1007/s00109-023-02373-w. Online ahead of print.ABSTRACTReperfusion after acute myocardial infarction further exaggerates cardiac injury and adverse remodeling. Irrespective of cardiac cell types, loss of specifically the α isoform of the protein kinase GSK-3 is protective in chronic cardiac diseases. However, the role of GSK-3α in clinically relevant ischemia/reperfusion (I/R)-induced cardiac injury is unknown. Here, we challenged cardiomyocyte-specific conditional GSK-3α knockout (cKO) and littermate control mice with I/R injury and investigated the underlying molecular mechanism ...
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Firdos Ahmad Hezlin Marzook Anamika Gupta Aseel Aref Kiran Patil Amir Ali Khan Mohamed A Saleh Walter J Koch James R Woodgett Rizwan Qaisar Source Type: research
Acetylcholinesterase inhibition protects against trastuzumab-induced cardiotoxicity through reducing multiple programmed cell death pathways
CONCLUSIONS: Donepezil exerted cardioprotection against TIC via attenuating mitochondrial dysfunction, oxidative stress, inflammation, and cardiomyocyte death, leading to improved LV function through mAChR activation. This suggests that donepezil could be a novel intervention strategy in TIC.PMID:37691124 | DOI:10.1186/s10020-023-00686-7
Source: Molecular Medicine - September 10, 2023 Category: Molecular Biology Authors: Thawatchai Khuanjing Chayodom Maneechote Benjamin Ongnok Nanthip Prathumsap Apiwan Arinno Titikorn Chunchai Busarin Arunsak Siriporn C Chattipakorn Nipon Chattipakorn Source Type: research
A Complex Interplay of DJ-1, LRRK2, and Nrf2 in the Regulation of Mitochondrial Function in Cypermethrin-Induced Parkinsonism
Mol Neurobiol. 2023 Sep 6. doi: 10.1007/s12035-023-03591-6. Online ahead of print.ABSTRACTCypermethrin impairs mitochondrial function, induces redox imbalance, and leads to Parkinsonism in experimental animals. Knockdown of deglycase-1 (DJ-1) gene, which encodes a redox-sensitive antioxidant protein, aggravates cypermethrin-mediated α-synuclein overexpression and oxidative alteration of proteins. DJ-1 is also reported to be essential for maintaining stability of nuclear factor erythroid 2-related factor 2 (Nrf2), shielding cells against oxidative insult. Leucine-rich repeat kinase 2 (LRRK2), another protein associated wit...
Source: Molecular Medicine - September 6, 2023 Category: Molecular Biology Authors: Alika Sarkar Mahendra Pratap Singh Source Type: research
3-Acetyldeoxynivalenol induces apoptosis, barrier dysfunction and endoplasmic reticulum stress by inhibiting mTORC1-dependent autophagy in porcine enterocytes
In conclusion, our research indicated that the mTORC1 protein and autophagy played a key role in the 3-Ac-DON-induced cytotoxic in IPEC cells, which will provide new therapeutic targets and ideas for 3-AC-DON-mediated intestinal injury.PMID:37659622 | DOI:10.1016/j.cbi.2023.110695
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Tongkun Zhang Jun Bai Guangye Chen Zhaohui Chen Shenming Zeng Ying Yang Zhenlong Wu Source Type: research
Role of RIPK3 ‑CaMKII‑mPTP signaling pathway‑mediated necroptosis in cardiovascular diseases (Review)
Int J Mol Med. 2023 Oct;52(4):98. doi: 10.3892/ijmm.2023.5301. Epub 2023 Sep 1.ABSTRACTNecroptosis, which is distinct from apoptosis and necrosis, serves a crucial role in ontogeny and the maintenance of homeostasis. In the last decade, it has been demonstrated that the pathogenesis of cardiovascular diseases is also linked to necroptosis. Receptor interaction protein kinase (RIPK) 1, RIPK3 and mixed lineage kinase domain‑like protein serve vital roles in necroptosis. In addition to the aforementioned necroptosis‑related components, calcium/calmodulin‑dependent protein kinase II (CaMKII) has been identified as a nove...
Source: Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Sheng Chen Senhong Guan Zhaohan Yan Fengshan Ouyang Shuhuan Li Lanyuan Liu Jiankai Zhong Source Type: research
