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Repurposing of Clinically Approved Poly-(ADP-Ribose) Polymerase Inhibitors for the Therapy of Sepsis
Sepsis’ pathogenesis involves multiple mechanisms that lead to a dysregulation of the host's response. Significant efforts have been made in search of interventions that can reverse this situation and increase patient survival. Poly (ADP-polymerase) (PARP) is a constitutive nuclear and mitochondrial enzyme, which functions as a co-activator and co-repressor of gene transcription, thus regulating the production of inflammatory mediators. Several studies have already demonstrated an overactivation of PARP1 in various human pathophysiological conditions and that its inhibition has benefits in regulating intracellular proces...
Source: Shock - November 26, 2021 Category: Emergency Medicine Tags: Review Articles Source Type: research

Genes, Vol. 14, Pages 915: Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease
-Mon Miguel Ángel Alvarez-Mon Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a lesser extent, H2A in the cytoplasm. However, 20 min after assembly, histones lose acetylation marks. Moreover, new noncanonical functions have been described for HAT1, revealing its complexity and complicating the understanding of its functions. Re...
Source: Genes - April 14, 2023 Category: Genetics & Stem Cells Authors: Miguel A. Ortega Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Mar ía del Val Toledo Lobo Ignacio Garc ía-Tuñón Mar Royuela Natalio Garc ía-Honduvilla Julia Bujan Luis G. Guijarro Melchor Alvarez-Mon Miguel Ángel A Tags: Review Source Type: research

Understanding HAT1: A Comprehensive Review of Noncanonical Roles and Connection with Disease
Genes (Basel). 2023 Apr 14;14(4):915. doi: 10.3390/genes14040915.ABSTRACTHistone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a lesser extent, H2A in the cytoplasm. However, 20 min after assembly, histones lose acetylation marks. Moreover, new noncanonical functions have been described for HAT1, revealing its complexity and complicating th...
Source: Atherosclerosis - April 28, 2023 Category: Cardiology Authors: Miguel A Ortega Diego De Leon-Oliva Cielo Garcia-Montero Oscar Fraile-Martinez Diego Liviu Boaru Mar ía Del Val Toledo Lobo Ignacio Garc ía-Tuñón Mar Royuela Natalio Garc ía-Honduvilla Julia Bujan Luis G Guijarro Melchor Alvarez-Mon Miguel Ángel Alv Source Type: research