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I Never Thought Stroke Would Happen to Me
by Myra Wilson, Stroke Survivor On November 3, 2014, I was in nursing school working as a student nurse at a hospital in Seattle. My first sign that something was not quite right was when I was walking through the nursing station and both of my eyes went blurry. I could still see color but I couldn't see letters. It was blurry for about 30 seconds before clearing up again. I was going to lunch and went to give a report to another nurse. The nurse noticed while I was speaking that I slurred my speech. I didn't notice my speech was slurred at all. It was at that time that I experienced a sudden sharp pain on the right s...
Source: Healthy Living - The Huffington Post - May 13, 2016 Category: Consumer Health News Source Type: news

Cerebral small-vessel disease associated with COL4A1 and COL4A2 gene duplications
A nonsmoking woman, aged 44 years, presented with transient right-sided hemiparesis. CT showed leukoencephalopathy without infarction (figure). Blood pressure was normal. Blood count, plasma glucose levels, C-reactive protein, renal/liver function tests, cardiac enzymes, atrial natriuretic factor, HIV/syphilis/hepatitis B and C serology, and lactic acid levels were normal. Low-density lipoprotein (LDL) cholesterol levels were slightly elevated (1.25 g/L). Screening tests for prothrombotic disorders (serum fibrinogen, D-dimer, fibrin degradation products, antithrombin III level, protein C and S level, factor V Leiden, proth...
Source: Neurology - September 8, 2014 Category: Neurology Authors: Renard, D., Mine, M., Pipiras, E., Labauge, P., Delahaye, A., Benzacken, B., Tournier-Lasserve, E. Tags: Stroke in young adults, MRI, All Cerebrovascular disease/Stroke, Infarction, All Genetics CLINICAL/SCIENTIFIC NOTES Source Type: research

Time-Dependent Changes in Porcelain Aorta and Aortic Stenosis in a Patient with Systemic Lupus Erythematosus.
Authors: Hirose K, Kodera S, Daimon M, Komuro I Abstract Porcelain aorta, defined as extensive calcification of the ascending aorta or aortic arch, is a reported risk factor for embolic stroke during cardiac surgery. However, the time course of the progression of aortic calcification leading to porcelain aorta has not been elucidated. We herein describe a 70-year-old woman who was followed up for systemic lupus erythematosus and antiphospholipid syndrome for approximately 20 years. A routine computed tomography scan revealed progression of ascending aortic calcification to porcelain aorta. The calcification was abs...
Source: International Heart Journal - November 17, 2020 Category: Cardiology Tags: Int Heart J Source Type: research

Altered fibrin clot structure/function in patients with antiphospholipid syndrome: association with thrombotic manifestation.
Abstract We tested the hypothesis that plasma fibrin clot structure/function is unfavourably altered in patients with antiphospholipid syndrome (APS). Ex vivo plasma clot permeability, turbidity and susceptibility to lysis were determined in 126 consecutive patients with APS enrolled five months or more since thrombotic event vs 105 controls. Patients with both primary and secondary APS were characterized by 11% lower clot permeability (p<0.001), 4.8% shorter lag phase (p<0.001), 10% longer clot lysis time (p<0.001), and 4.7% higher maximum level of D-dimer released from clots (p=0.02) as compared to the ...
Source: Thrombosis and Haemostasis - March 20, 2014 Category: Hematology Authors: Celinska-Lowenhoff M, Iwaniec T, Padjas A, Musial J, Undas A Tags: Thromb Haemost Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research