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Endothelial Upregulation of Mechanosensitive Channel Piezo1 in Pulmonary Hypertension
Am J Physiol Cell Physiol. 2021 Oct 20. doi: 10.1152/ajpcell.00147.2021. Online ahead of print.ABSTRACTPiezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary arterial hypertension (PAH). Pulmonary arterial endothelial cells (PAECs) are constantly under mechanic stretch and shear stress that are sufficient to activate Piezo channels. Here we report that Piezo1 is significantly upregulated in PAECs from patients with idiopathic PAH and ...
Source: Am J Physiol Cell Ph... - October 20, 2021 Category: Cytology Authors: Ziyi Wang Jiyuan Chen Aleksandra Babicheva Pritesh P Jain Marisela Rodriguez Ramon J Ayon Keeley S Ravellette Linda Wu Francesca Balistrieri Haiyang Tang Xiaomin Wu Tengteng Zhao Stephen M Black Ankit A Desai Joe G N Garcia Xin Sun John Y-J Shyy Daniela V Source Type: research

Extracellular adenosine enhances pulmonary artery vasa vasorum endothelium cell barrier function via the Gi/ELMO1/Rac1/PKA-dependent signaling mechanisms.
In this study we investigated in more detail the mechanisms linking Gi activation to downstream barrier protection pathways. Using a small interference RNA (siRNA) technique and Transendothelial Electrical Resistance (TER) assay, we found that the adaptor protein, ELMO1, the tyrosine phosphatase Shp2, and atypical Gi- and Rac-mediated PKA activation are implicated in VVEC barrier enhancement. In contrast, the actin-interacting GTP-binding protein, girdin and the PAK1 downstream target, LIM kinase, are not involved in this response. In addition, adenosine-dependent cytoskeletal rearrangement involves activation of cofilin a...
Source: Am J Physiol Cell Ph... - May 19, 2020 Category: Cytology Authors: Verin AD, Batori R, Kovacs-Kasa A, Cherian-Shaw M, Kumar S, Czikora I, Karoor V, Strassheim D, Stenmark KR, Gerasimovskaya E Tags: Am J Physiol Cell Physiol Source Type: research

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.
Abstract Pulmonary arterial adventitial fibroblasts (PAF), the most abundant cellular constituent of adventitia, act as a key regulator of pulmonary vascular wall structure and function from the outside-in. Previous studies indicate that Transient Receptor Potential Vanilloid 4 (TRPV4) channel plays an important role in the development of pulmonary hypertension (PH), but no attention has been given so far to its role in adventitial remodeling. In the present study, we thus investigated TRPV4 implication in PAF activation occurring in PH. First, we isolated and cultured PAF from rat adventitial intrapulmonary arter...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 5, 2019 Category: Cytology Authors: Cussac LA, Cardouat G, Tiruchellvam Pillai N, Campagnac M, Robillard P, Montillaud A, Guibert C, Gailly P, Marthan R, Quignard JF, Savineau JP, Ducret T Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

A study on the involvement of fatty acid synthase in right ventricle dysfunction in pulmonary hypertension.
In conclusion, our study reveals that inhibition of FAS decreases RV hypertrophy and improves cardiac function associated with PH by perking up metabolic functions. PMID: 31465767 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - August 25, 2019 Category: Cytology Authors: Singh N, Shafiq M, Jagavelu K, Hanif K Tags: Exp Cell Res Source Type: research

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