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Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Educational and behavioural interventions for anticoagulant therapy in patients with atrial fibrillation.
CONCLUSIONS: This review demonstrates that there is insufficient evidence to draw definitive conclusions regarding the impact of educational or behavioural interventions on TTR in AF patients receiving OAT. Thus, more trials are needed to examine the impact of interventions on anticoagulation control in AF patients and the mechanisms by which they are successful. It is also important to explore the psychological implications for patients suffering from this long-term chronic condition. PMID: 28378924 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 5, 2017 Category: Journals (General) Authors: Clarkesmith DE, Pattison HM, Khaing PH, Lane DA Tags: Cochrane Database Syst Rev Source Type: research

My debilitating endometriosis symptoms – Kate ’ s story
Hi, I’m Kate, 39, married with no children. I had always suffered from heavy and painful periods but this had mostly been managed by taking the combined pill. My periods remained heavy and I suffered from some flooding but this was manageable with planning! Approximately 7 years ago my periods became worse and I started to experience more symptoms such as regular and frequent abdominal pain, random bleeding, bloating, very painful intercourse and things just didn’t feel right. Anyway, I went to the Dr’s who straight away suggested that it sounded like I had endometriosis and referred me to a consultant. A...
Source: The Hysterectomy Association - March 1, 2017 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Health endometriosis hysterectomy stories Source Type: news

What's hot that the other lot got
Fibrinolysis for patients with intermediate-risk PE The use of fibrinolysis for normotensive patients with an intermediate risk of death after acute pulmonary embolism (PE) remains a controversial topic. The PIETHO trial (N Engl J Med 2014;370:1402–11) was a multicentre, double-blind trial, in which 1006 patients with acute PE and evidence of right ventricular dysfunction on echocardiography or CT, as well as positive cardiac troponin test, were randomly assigned to initial treatment with tenecteplase plus heparin, or placebo plus heparin. The primary outcome of death or haemodynamic compromise within 7 days of rando...
Source: Thorax - May 14, 2014 Category: Respiratory Medicine Authors: Rolin, S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Inflammation, Venous thromboembolism, Pulmonary embolism, Radiology (diagnostics) Chest clinic Source Type: research

Use of floss/interdental brushes is associated with lower risk for new cardiovascular events among patients with coronary heart disease
ConclusionsThese findings suggest that flossing and brushing of interdental spaces might reduce the risk for new cardiovascular events among patients with CHD. The hypothesis that interdental cleaning per se reduces the risk of new cardiovascular events should be examined in an interventional study.
Source: Journal of Periodontal Research - May 14, 2014 Category: Dentistry Authors: S. Reichert, A. Schlitt, V. Beschow, A. Lutze, S. Lischewski, T. Seifert, T. Dudakliewa, R. Gawe, K. Werdan, B. Hofmann, H.‐G. Schaller, S. Schulz Tags: Original Article Source Type: research