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Polysaccharide-based (kappa carrageenan/carboxymethyl chitosan) nanofibrous membrane loaded with antifibrinolytic drug for rapid hemostasis- in vitro and in vivo evaluation
Int J Biol Macromol. 2023 Jul 12:125786. doi: 10.1016/j.ijbiomac.2023.125786. Online ahead of print.ABSTRACTThis work aimed to establish a novel membrane consisting of hemostatic polysaccharides, kappa-carrageenan (KC), and carboxymethyl chitosan (CMC) in tandem with polyvinyl alcohol that spun together as a matrix and loaded with tranexamic acid (TXA) as antifibrinolytic agent for further coagulation effect during and after oral surgeries. The electrospinning of KC was done for the first time and in comparison of CMC has better hemostatic efficacy. The effect of the hemostat was investigated by its surface morphology (SEM...
Source: International Journal of Biological Macromolecules - July 14, 2023 Category: Biochemistry Authors: Sara Salamzadeh Salmasi Morteza Ehsani Mojgan Zandi Mahdi Saeed Mike Sabeti Source Type: research

Anti-inflammatory mechanisms of eucalyptol rich Eucalyptus globulus essential oil alone and in combination with flurbiprofen
This study was designed to evaluate the anti-inflammatory, analgesic and anti-pyretic properties of Eucalyptus globulus essential oil alone and in combination with flurbiprofen. GC-MS analysis was performed to screen chemical composition of oil. In vitro anti-inflammatory assay (membrane stabilization assay) and in vivo inflammatory acute (carrageenan and histamine-induced paw oedema) and chronic (cotton pellet-induced granuloma and Complete Freund's adjuvant-induced arthritis) models were performed to check anti-inflammatory properties. Acetic acid-induced algesia and yeast-induced pyrexia models were performed to chec...
Source: Cancer Control - May 14, 2023 Category: Cancer & Oncology Authors: Bushra Arooj Sajid Asghar Mohammad Saleem Syed Haroon Khalid Muhammad Asif Tahir Chohan Ikram Ullah Khan Hafiz Muhammad Zubair Hafiza Sidra Yaseen Source Type: research

The Efficacy of Advanced Platelet-rich Fibrin in Revascularization of Immature Necrotic Teeth
CONCLUSION: Regenerative endodontic procedure for traumatized immature nonvital teeth with either conventional blood clot or A-PRF as scaffold was comparable, except in cases where adequate bleeding cannot be achieved.CLINICAL SIGNIFICANCE: Advanced platelet-rich fibrin provides a suitable scaffold that can be used in REP of teeth with close proximity to vital structures such as inferior alveolar nerve (IAN) or mental nerve, where using a sharp instrument to induce bleeding can cause damage and also in cases where adequate bleeding cannot be achieved.PMID:36440520
Source: J Contemp Dent Pract - November 28, 2022 Category: Dentistry Authors: Amr Yosry Abd El-Hady Amany El-Said Badr Source Type: research

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