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Condition: Gastroenteritis
Vaccination: Veterinary Vaccinations
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Total 175 results found since Jan 2013.
Identification and Genome Characterization of Novel Feline Parvovirus Strains Isolated in Shanghai, China
Curr Issues Mol Biol. 2023 Apr 20;45(4):3628-3639. doi: 10.3390/cimb45040236.ABSTRACTFeline panleukopenia virus (FPV) is the causative agent of hemorrhagic gastroenteritis in feline animals. FPV has been evolving over time, and there have been several different strains of the virus identified. Some of these strains may be more virulent or more resistant to current vaccines than others, which highlights the importance of ongoing research and monitoring of FPV evolution. For FPV genetic evolution analysis, many studies focus on the main capsid protein (VP2), but limited information is available on the nonstructural gene NS1 ...
Source: Current Issues in Molecular Biology - May 15, 2023 Category: Molecular Biology Authors: Chengqian Liu Fusheng Si Hong Li Jun Gao Fengping Sun Huili Liu Jianzhong Yi Source Type: research
Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency
Vaccine. 2022 Jul 21:S0264-410X(22)00892-1. doi: 10.1016/j.vaccine.2022.07.017. Online ahead of print.ABSTRACTRotavirus infections remain a leading cause of morbidity and mortality among infants residing in low- and middle-income countries. To address the large need for protection from this vaccine-preventable disease we are developing a trivalent subunit rotavirus vaccine which is currently being evaluated in a multinational Phase 3 clinical trial for prevention of serious rotavirus gastroenteritis. Currently, there are no universally accepted in vivo or in vitro models that allow for correlation of field efficacy to an i...
Source: Vaccine - July 25, 2022 Category: Allergy & Immunology Authors: David McAdams Marcus Estrada David Holland Jasneet Singh Nishant Sawant John M Hickey Prashant Kumar Brian Plikaytis Sangeeta B Joshi David B Volkin Robert Sitrin Stan Cryz Jessica A White Source Type: research
Molecular analysis of the full-length VP2 gene of Brazilian strains of canine parvovirus 2 shows genetic and structural variability between wild and vaccine strains
Virus Res. 2022 Mar 12:198746. doi: 10.1016/j.virusres.2022.198746. Online ahead of print.ABSTRACTCanine parvovirus 2 (CPV-2), a highly contagious virus, affects dogs worldwide. Infected animals present severe and acute gastroenteritis which may culminate in death. CPV-2 VP2 protein is responsible for important biological functions related to virus-host interactions. Herein we obtained VP2 full-length gene sequences from Brazilian dogs with bloody diarrhea (n=15) and vaccine strains (n=7) produced by seven different laboratories and marketed in Brazil. All wild sequences and one vaccine strain were classified as CPV-2b and...
Source: Virus Research - March 16, 2022 Category: Virology Authors: L M N Silva M R Santos J A Carvalho O V Carvalho E S Favarato J L R Fietto G C Bressan A Silva-J únior Source Type: research
Safety and immunogenicity studies in animal models support clinical development of a bivalent norovirus-like particle vaccine produced in plants
Vaccine. 2022 Jan 18:S0264-410X(22)00022-6. doi: 10.1016/j.vaccine.2022.01.009. Online ahead of print.ABSTRACTNoroviruses (NoV) are the leading cause of epidemic acute gastroenteritis in humans worldwide. A safe and effective vaccine that prevents NoV infection or minimizes NoV disease burden is needed, especially for children and the elderly who are particularly susceptible to NoV disease. A plant-based expression system (magnICON®) was used to manufacture two different virus-like particle (VLP) immunogens derived from human NoV genogroups I and II, genotype 4 (GI.4 and GII.4), which were subsequently blended 1:1 (w/w) i...
Source: Vaccine - January 22, 2022 Category: Allergy & Immunology Authors: Daniel Tus é Maria Malm Kirsi Tamminen Andr é Diessner Frank Thieme Franziska Jarczowski Vesna Blazevic Victor Klimyuk Source Type: research
Evaluation of a Campylobacter jejuni N-glycan-ExoA glycoconjugate vaccine to reduce C. jejuni colonisation in chickens
In this study, protein glycan coupling technology was used to add up to ten C. jejuni N-glycans onto a detoxified form of Pseudomonas aeruginosa exotoxin A (ExoA). The glycoprotein, G-ExoA, was evaluated for efficacy against intestinal colonisation of White Leghorn chickens by C. jejuni strains M1 and 11168H relative to unglycosylated ExoA. Chickens were challenged with the minimum dose required for reliable colonisation, which was 102 colony-forming units (CFU) for strain M1 and and 104 CFU for strain 11168H. Vaccine-specific serum IgY was detected in chickens vaccinated with both ExoA and G-ExoA. However, no reduction in...
Source: Vaccine - November 20, 2021 Category: Allergy & Immunology Authors: Prerna Vohra Cosmin Chintoan-Uta Abi Bremner Marta Mauri Vanessa S Terra Jon Cuccui Brendan W Wren Lonneke Vervelde Mark P Stevens Glycoengineering of Veterinary Vaccines Consortium Source Type: research
