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Condition: Cough
Vaccination: Whooping Cough (Pertussis) Vaccine
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Total 207 results found since Jan 2013.
T cell reactivity to Bordetella pertussis is highly diverse regardless of childhood vaccination
Cell Host Microbe. 2023 Jul 16:S1931-3128(23)00266-4. doi: 10.1016/j.chom.2023.06.015. Online ahead of print.ABSTRACTThe incidence of whooping cough due to Bordetella pertussis (BP) infections has increased recently. It is believed that the shift from whole-cell pertussis (wP) vaccines to acellular pertussis (aP) vaccines may be contributing to this rise. While T cells are key in controlling and preventing disease, nearly all knowledge relates to antigens in aP vaccines. A whole-genome mapping of human BP-specific CD4+ T cell responses was performed in healthy vaccinated adults and revealed unexpected broad reactivity to h...
Source: Cell Host and Microbe - July 25, 2023 Category: Microbiology Authors: Ricardo da Silva Antunes Emily Garrigan Lorenzo G Quiambao Sandeep Kumar Dhanda Daniel Marrama Luise Westernberg Eric Wang Adam Abawi Aaron Sutherland Sandra K Armstrong Timothy J Brickman John Sidney April Frazier Tod J Merkel Bjoern Peters Alessandro Se Source Type: research
Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations
Clin Microbiol Rev. 2023 Jun 12:e0016422. doi: 10.1128/cmr.00164-22. Online ahead of print.ABSTRACTBordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At...
Source: Clinical Microbiology Reviews - June 12, 2023 Category: Microbiology Authors: Beatriz Miguelena Chamorro Karelle De Luca Gokul Swaminathan St éphanie Longet Egbert Mundt St éphane Paul Source Type: research
Nasal vaccines for pertussis
Curr Opin Immunol. 2023 Jun 10;84:102355. doi: 10.1016/j.coi.2023.102355. Online ahead of print.ABSTRACTWhooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults and in infants born to vaccinated mothers. However, they do not prevent nasal infection, allowing asymptomatic transmission of B. pertussis. Studies in animal models have demonstrated that, unlike natural infection, immunization with aP vaccines fails to induce secretory immunoglobulin A (IgA) or i...
Source: Current Opinion in Immunology - June 12, 2023 Category: Allergy & Immunology Authors: Pauline Schmitt Lisa Borkner Seyed Davoud Jazayeri Karen N McCarthy Kingston Hg Mills Source Type: research
Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations
Clin Microbiol Rev. 2023 Jun 12:e0016422. doi: 10.1128/cmr.00164-22. Online ahead of print.ABSTRACTBordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At...
Source: Clinical Microbiology Reviews - June 12, 2023 Category: Microbiology Authors: Beatriz Miguelena Chamorro Karelle De Luca Gokul Swaminathan St éphanie Longet Egbert Mundt St éphane Paul Source Type: research
Nasal vaccines for pertussis
Curr Opin Immunol. 2023 Jun 10;84:102355. doi: 10.1016/j.coi.2023.102355. Online ahead of print.ABSTRACTWhooping cough, caused by Bordetella pertussis, is still a major cause of morbidity and mortality worldwide. Current acellular pertussis (aP) vaccines induce potent circulating IgG and prevent severe disease in children/adults and in infants born to vaccinated mothers. However, they do not prevent nasal infection, allowing asymptomatic transmission of B. pertussis. Studies in animal models have demonstrated that, unlike natural infection, immunization with aP vaccines fails to induce secretory immunoglobulin A (IgA) or i...
Source: Current Opinion in Immunology - June 12, 2023 Category: Allergy & Immunology Authors: Pauline Schmitt Lisa Borkner Seyed Davoud Jazayeri Karen N McCarthy Kingston Hg Mills Source Type: research
Bordetella bronchiseptica and Bordetella pertussis: Similarities and Differences in Infection, Immuno-Modulation, and Vaccine Considerations
Clin Microbiol Rev. 2023 Jun 12:e0016422. doi: 10.1128/cmr.00164-22. Online ahead of print.ABSTRACTBordetella pertussis and Bordetella bronchiseptica belong to the genus Bordetella, which comprises 14 other species. B. pertussis is responsible for whooping cough in humans, a severe infection in children and less severe or chronic in adults. These infections are restricted to humans and currently increasing worldwide. B. bronchiseptica is involved in diverse respiratory infections in a wide range of mammals. For instance, the canine infectious respiratory disease complex (CIRDC), characterized by a chronic cough in dogs. At...
Source: Clinical Microbiology Reviews - June 12, 2023 Category: Microbiology Authors: Beatriz Miguelena Chamorro Karelle De Luca Gokul Swaminathan St éphanie Longet Egbert Mundt St éphane Paul Source Type: research
