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Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All-cause Mortality: O'Keefe JH, Bhatti SK, Patil HR. J Am Coll Cardiol 2013;62:1043−51.
This study examines existing data regarding coffee consumption and its effect on health and all-cause mortality. Coffee consumption confers a benefit in the reduction of Type II diabetes mellitus (T2DM). There was significant reduction in a dose-dependent relationship of coffee consumption and reduction of T2DM. Caffeinated and noncaffeinated beverages confer the same benefit. The authors conclude that coffee's effect on serum lipids is a dose-dependent increase in serum total cholesterol and a nonsignificant increase in low-density lipoprotein concentrations in only boiled preparations of coffee, but not for filtered coff...
Source: The Journal of Emergency Medicine - April 24, 2014 Category: Emergency Medicine Authors: Java Tunson Tags: Abstracts Source Type: research

Effects of Habitual Coffee Consumption on Cardiometabolic Disease, Cardiovascular Health, and All-Cause Mortality
Coffee, after water, is the most widely consumed beverage in the United States, and is the principal source of caffeine intake among adults. The biological effects of coffee may be substantial and are not limited to the actions of caffeine. Coffee is a complex beverage containing hundreds of biologically active compounds, and the health effects of chronic coffee intake are wide ranging. From a cardiovascular (CV) standpoint, coffee consumption may reduce the risk of type 2 diabetes mellitus and hypertension, as well as other conditions associated with CV risk such as obesity and depression; but it may adversely affect lipi...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - September 9, 2013 Category: Cardiology Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research