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Condition: Asthma
Drug: Acetylcysteine
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Total 52 results found since Jan 2013.
Evaluation of cigarette smoke-induced oxidative stress and inflammation in BEAS-2B cells based on a lung microfluidic chip
Food Chem Toxicol. 2023 Apr 14;176:113787. doi: 10.1016/j.fct.2023.113787. Online ahead of print.ABSTRACTOxidative stress and inflammation induced by cigarette smoking are associated with the pathology process of various chronic respiratory diseases, including asthma, emphysema, chronic obstructive pulmonary disease and cancer. Compared with conventional cell culture techniques, microfluidic chips can provide a continuous nutrient supply, mimic the in vivo physiological microenvironment of the cells, and conduct an integrated and flexible analysis of cell status and functions. Here, we designed and fabricated a bionic-lung...
Source: Food and Chemical Toxicology - April 16, 2023 Category: Food Science Authors: Jingxian Xue Zezhi Li Xiang Li Chenfeng Hua Pingping Shang Junwei Zhao Kejian Liu Fuwei Xie Source Type: research
Autocrine TGF-alpha is associated with Benzo(a)pyrene-induced mucus production and MUC5AC expression during allergic asthma
CONCLUSION: Autocrine TGF-α was associated with BaP-induced MUC5AC expression in vitro and in vivo. BaP induced TGF-α secretion by activating AhR and producing ROS, which led to activation of the EGFR-ERK pathway.PMID:36068759 | DOI:10.1016/j.ecoenv.2022.113833
Source: Ecotoxicology and Environmental Safety - September 7, 2022 Category: Environmental Health Authors: Yipeng Sun Xiayi Miao Linyun Zhu Jinjin Liu Yuhua Lin Guiling Xiang Xiaodan Wu Xiaobiao Wang Zhenhua Ni Shanqun Li Source Type: research
Study of the Effects of N-acetylcysteine on Inflammatory Biomarkers and Disease Activity Score in Patients with Rheumatoid Arthritis
Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):574-583. doi: 10.18502/ijaai.v20i5.7407.ABSTRACTRheumatoid arthritis (RA) is considered as an autoimmune-related condition in which the overproduction of pro-inflammatory cytokines leads to an inflammatory cascade. N-acetylcysteine (NAC) is a potent anti-inflammatory and anti-oxidant agent. We aimed to explore the impact of oral NAC on cytokines activities and clinical indicators in RA patients. In this placebo-controlled randomized double-blind clinical trial, 41 active RA patients were allocated in either NAC (600 mg, twice a day) or placebo group, as add-on therapy to the...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 19, 2021 Category: Allergy & Immunology Authors: Faezeh Jamali Arman Ahmadzadeh Zahra Sahraei Jamshid Salamzadeh Source Type: research
