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Condition: Asthma
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Total 404 results found since Jan 2013.
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling
Am J Respir Cell Mol Biol. 2021 Jul 22. doi: 10.1165/rcmb.2021-0106OC. Online ahead of print.ABSTRACTExaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors (GPCRs) causes airway hyperresponsiveness (AHR) in asthma. Activation of Gq-coupled GPCRs leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP3) and diacylglycerol (DAG). DAG signaling is terminated by the action of DAG kinase (DGK) that converts DAG into phosphatidic acid (PA). Our previous study demonstrated that DGKα and ζ isoform knockout mice are protected from the development of all...
Source: American Journal of Respiratory Cell and Molecular Biology - July 22, 2021 Category: Molecular Biology Authors: Pawan Sharma Santosh K Yadav Sushrut D Shah Elham Javed John M Lim Shi Pan Ajay P Nayak Reynold A Panettieri Raymond B Penn Taku Kambayashi Deepak A Deshpande Source Type: research
Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
Store-operated Calcium Entry-associated Regulatory Factor Regulates Airway Inflammation and Airway Remodeling in Asthma Mice Models
CONCLUSIONS: SARAF plays a protective role against airway inflammation and remodeling in asthma mice models by blunting SOCE; SARAF may also be a functional regulating factor of hASMCs.PMID:34231388 | DOI:10.1152/ajplung.00079.2020
Source: Am J Physiol Lung Ce... - July 7, 2021 Category: Respiratory Medicine Authors: Yi-Min Wang Wen-Juan Xu Lin-Li Xiang Mei Ding Jin-Jin Zhang Jing-Ya Lu Bao-Juan Xie Ya-Dong Gao Source Type: research
Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway
CONCLUSIONS: These results implied that ERK, PEA3, and AP-1 participate in hypoxia-induced Pref-1 expression in human lung fibroblasts.PMID:34229599 | DOI:10.1186/s10020-021-00336-w
Source: Molecular Medicine - July 7, 2021 Category: Molecular Biology Authors: Wun-Hao Cheng Chia-Ling Chen Jing-Yun Chen Chien-Huang Lin Bing-Chang Chen Source Type: research
