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Specialty: Cancer & Oncology
Condition: Asthma
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Total 71 results found since Jan 2013.
IL-25 Impact on Malignant B Cells Survival and T Cells Activation in Chronic Lymphocytic Leukemia
Iran J Allergy Asthma Immunol. 2023 Jun 16;22(3):299-311. doi: 10.18502/ijaai.v22i3.13058.ABSTRACTT cell dysregulation and shift to T helper 2 responses, boosting tumor microenvironment support, contributes to the survival of leukemic B cells in Chronic Lymphocytic Leukemia. Interleukin (IL)-25 is involved in the initiation of T helper 2 cell responses. Signal transduction of IL-25 begins with the heterodimer receptor (IL-17RA/IL-17RB). The presence of IL-25 in the tumor microenvironment may affect the supportive effects of T cells in the surrounding tumor cell environment. The purpose of this study was to evaluate the rol...
Source: Cancer Control - July 31, 2023 Category: Cancer & Oncology Authors: Mehrnoosh Pashei Farahnaz Ghahremanfard Ehsan Manouchehri Doulabi Maral Hemmati Fatemeh Pak Parviz Kokhaei Source Type: research
FLI1 Regulates Histamine Decarboxylase Expression to Control Inflammation Signaling and Leukemia Progression
CONCLUSION: These results suggest a role for the transcription factor FLI1 in inflammation signaling and leukemia progression through HDC and point to the HDC pathway as potential therapeutics for FLI1-driven leukemia.PMID:37193069 | PMC:PMC10183177 | DOI:10.2147/JIR.S401566
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: Jifen Hu Jian Gao Chunlin Wang Wuling Liu Anling Hu Xiao Xiao Yi Kuang Kunlin Yu Babu Gajendran Eldad Zacksenhaus Weidong Pan Yaacov Ben-David Source Type: research
Genetic ancestry is associated with asthma, and this could be modified by environmental factors. A systematic review
Clin Exp Allergy. 2023 Apr 13. doi: 10.1111/cea.14308. Online ahead of print.NO ABSTRACTPMID:37051940 | DOI:10.1111/cea.14308
Source: Clinical Lung Cancer - April 13, 2023 Category: Cancer & Oncology Authors: Jonathan Pham Dinh S Bui Caroline J Lodge Michael J Abramson Adrian J Lowe Shuai Li Aung K Win Mark Hew Shyamali C Dharmage Source Type: research
Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis
CONCLUSIONS: Our results suggest that pediatric AD skin shows aberrant lipid profiles, and these alterations are associated with skin microbial dysbiosis and cutaneous barrier dysfunction.PMID:37021505 | DOI:10.4168/aair.2023.15.2.186
Source: Cancer Control - April 6, 2023 Category: Cancer & Oncology Authors: Jihyun Kim Byung Eui Kim Elena Goleva Evgeny Berdyshev Jaewoong Bae Seokjin Kim Hye-Young Kim Un Ha Lee Myoung Shin Kim Minyoung Jung Hyunmi Kim Jinyoung Lee Donald Y M Leung Kangmo Ahn Source Type: research
Investigating the Safety and Efficacy of the Synthetic Drug Herbix on Immune Responses Involved in the Treatment of a Mouse Model of Herpes Simplex Virus
In this study, 25 male BALB/c mice were used to conduct a mouse model of herpes by subcutaneously injecting an HSV-1 suspension (100 µL of 1× PFU/mL). The mice were divided into 5 groups with groups 1 to 3 designated as intervention groups, and groups 4 and 5 serving as positive and negative control groups, respectively. After 2 days of virus inoculation, the mice were treated with different concentrations of Herbix (100, 200, and 300 mg/mL) via subcutaneous injection. Mice Blood samples (0.5 to 1 mL) were taken from the mice before and after the experiments, and after three-week follow-up period, the mice were sacrifice...
Source: Cancer Control - April 1, 2023 Category: Cancer & Oncology Authors: Mohammad Ali Khodadoust Gholam Reza Keramatian Najmeh Kaffash Farkhad Jalil Tavakol-Afshari Source Type: research
MicroRNA-122 Is More Effective than Rapamycin in Inhibition of Epithelial-mesenchymal Transition and mTOR Signaling Pathway in Triple Negative Breast Cancer
Iran J Allergy Asthma Immunol. 2023 Feb 20;22(1):46-61. doi: 10.18502/ijaai.v22i1.12006.ABSTRACTThe fundamental mechanism responsible for the aggressiveness of metastatic cancers such as triple-negative breast cancer (TNBC) is the epithelial-mesenchymal transition (EMT). In cancer microenvironments, the Phosphoinositide 3-kinases (PI3K)-Akt- mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating the EMT mechanism. The current study focuses on the impacts of rapamycin, a newly retargeted chemotherapeutic agent against mTOR, and MicroRNA (miR)-122 on the aggressive behavior of TNBC. The ha...
Source: Cancer Control - April 1, 2023 Category: Cancer & Oncology Authors: Majdedin Ghalavand Ruhollah Dorostkar Hojat Borna Samira Mohammadi-Yeganeh Seyed Mahmood Hashemi Source Type: research
Pathogenesis of allergic diseases and implications for therapeutic interventions
Signal Transduct Target Ther. 2023 Mar 24;8(1):138. doi: 10.1038/s41392-023-01344-4.ABSTRACTAllergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence rates of these diseases are attracting increasing attention. The pathogenesis of allergic diseases is complex and involves many factors, including maternal-fetal environment, living environment, genetics, epigenetics, and the body's immune status. The pathogenesis of allergic disease...
Source: Cancer Control - March 25, 2023 Category: Cancer & Oncology Authors: Ji Wang Yumei Zhou Honglei Zhang Linhan Hu Juntong Liu Lei Wang Tianyi Wang Haiyun Zhang Linpeng Cong Qi Wang Source Type: research
Exploring Factors Underlying Poorly-Controlled Asthma in Adults by Integrating Phenotypes and Genotypes Associated with Obesity and Asthma: A Case-Control Study
CONCLUSION: The prediction model integrating obesity-asthma phenotypes and genotypes for poorly-controlled asthma can facilitate the prediction of high-risk asthma and provide potential targets for novel treatment.PMID:36714050 | PMC:PMC9875574 | DOI:10.2147/JAA.S397067
Source: Cancer Control - January 30, 2023 Category: Cancer & Oncology Authors: Hung-Ling Huang Ying-Jhen Huang Yi-Chi Chu Chia-Wei Chen Hsin-Chou Yang Jing-Shiang Hwang Chun-Houh Chen Ta-Chien Chan Source Type: research
Is your kid actin out? A series of six patients with inherited ARPC1B deficiency and review of the literature
CONCLUSION: ARPC1B deficiency has a variable and heterogeneous clinical spectrum, expanded by these cases to include keloid scars and Epstein-Barr virus chronic hepatitis. A novel deletion in exon 8 is shared by three unrelated families and might be the result of a founder effect.PMID:36708766 | DOI:10.1016/j.jaip.2022.12.045
Source: Clinical Lung Cancer - January 28, 2023 Category: Cancer & Oncology Authors: Estefan ía Vásquez-Echeverri Marco Antonio Yamazaki-Nakashimada Edna Venegas Montoya Selma Cecilia Scheffler Mendoza Lina Maria Castano-Jaramillo Edgar Alejandro Medina-Torres Maria Edith Gonz ález-Serrano Melissa Espinosa-Navarro Juan Carlos Bustamant Source Type: research
Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions
CONCLUSION: This is the first epigenetic study based on whole genome sequencing to identify marked dysregulation of enhancer regions as a hallmark of childhood asthma.PMID:36704932 | DOI:10.1111/all.15658
Source: Cancer Control - January 27, 2023 Category: Cancer & Oncology Authors: Loreen Th ürmann Matthias Kl ös Sebastian D Mackowiak Matthias Bieg Tobias Bauer Naveed Ishaque Marey Messingschlager Carl Herrmann Stefan R öder Mario Bauer Sascha Sch äuble Erik Faessler Udo Hahn Dieter Weichenhan Oliver M ücke Christoph Plass Mich Source Type: research
Effects of Neutrophil and Eosinophil Extracellular Trap Formation on Refractoriness in Chronic Rhinosinusitis With Nasal Polyps
CONCLUSIONS: The results of this study suggest that tissue Eosinophilia and EETosis may play a prognostic role, primarily in CRSwNP and thattissue neutrophilia and NETosis can play as prognostic biomarkers in neutrophilic CRSwNP.PMID:36693361 | DOI:10.4168/aair.2023.15.1.94
Source: Cancer Control - January 24, 2023 Category: Cancer & Oncology Authors: Hyunkyung Cha Hee-Suk Lim Jin-A Park Ara Jo Hyun Tae Ryu Do Won Kim Jeong Kyou Kim Seung-No Hong Hyun-Woo Shin Dae Woo Kim Source Type: research
Hypersensitivity reactions to folinic acid: mechanisms involved based on two case reports and a literature review
Allergy Asthma Clin Immunol. 2022 Dec 22;18(1):107. doi: 10.1186/s13223-022-00752-5.NO ABSTRACTPMID:36550565 | DOI:10.1186/s13223-022-00752-5
Source: Clinical Colorectal Cancer - December 22, 2022 Category: Cancer & Oncology Authors: Matve ï Apraxine Marc Van den Eynde Astrid De Cuyper Fran çoise Pirson Source Type: research
