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Neuromuscular blocking agent re-exposure in a retrospective cohort with neuromuscular blocking agent-associated anaphylaxis
CONCLUSION: Chemical structural similarities may contribute to the cross-reactivity of NMBAs in skin tests. Despite the high negative predictability of skin tests for suspected NMBA-induced anaphylaxis, the potential risk of recurrent anaphylaxis has not been eliminated.PMID:37356714 | DOI:10.1016/j.anai.2023.06.023
Source: Annals of Allergy, Asthma and Immunology - June 25, 2023 Category: Allergy & Immunology Authors: Jiung Jeong Jeong-Eun Yun Hyun Jee Kim Ji-Young Jang Jang Ho Seo Suh Young Lee Won Ho Kim Jeong-Hwa Seo Hye-Ryun Kang Source Type: research

Risk Factors for Recurrence of Nasal Polyps after Endoscopic Sinus Surgery in Patients with Allergic Chronic Rhino Sinusitis
AbstractRhino sinusitis, is a common inflammatory disease that affects the nasal cavity and paranasal sinuses in millions of individuals. Chronic sinusitis patients complain of a combination of nasal obstruction, rhinorrhea, post nasal drip and facial pain. To identify the risk factors of the recurrence of nasal polyps in chronic rhino sinusitis patients after endoscopic sinus surgery. After a review of 60 patients with chronic rhino sinusitis with failed medical treatment requiring FESS presenting in Kasr Alainy Hospital in Cairo University and October 6 University Hospital from May 2022 to March 2023. All patients were s...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - June 23, 2023 Category: ENT & OMF Source Type: research

Children with Near-Fatal Asthma: The Use of Inhaled Volatile Anesthetics and Extracorporeal Membrane Oxygenation
Pediatric Allergy, Immunology, and Pulmonology,Volume 35, Issue 4, Page 170-173, December 2022.
Source: Pediatric, Allergy, Immunology, and Pulmonology - December 15, 2022 Category: Respiratory Medicine Authors: Chasity M. Custer Erika R. O'Neil Janaki Paskaradevan Brian J. Rissmiller Maria C. Gazzaneo Source Type: research

Knowledge of anaphylaxis management among latin american dentists
Anaphylaxis is a severe and potentially life-threatening disorder that could occur in dental practice and can be triggered by antibiotics, chlorhexidine, local and general anesthetic and latex. The aim of our study is to assess the knowledge of anaphylaxis management among Latin American dentists.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: J. Gallardo Bastidas, H. Mautong, G. Rouillon Borrero, K. Robles-Velasco, B. Intriago, J. Martin-Delgado, I. Cherrez-Ojeda Tags: P018 Source Type: research

A case of anaphylaxis to sugammadex skin prick testing
Sugammadex is a modified gamma-cyclodextrin gaining increasingly common usage as an anesthetic medication for the rapid reversal of the neuromuscular blocking agents rocuronium and vecuronium. While considered safer than traditional reversal agents, sugammadex is becoming more widely recognized as a rare cause of peri-operative anaphylaxis. There are no standardized skin prick testing protocols or commercially available IgE assays for sugammadex, although previous literature has used an undiluted concentration of 100mg/ml for epicutaneous skin testing.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: M. Dittus, B. Navetta-Modrov Tags: M012 Source Type: research

Global patterns of drug allergy-induced fatalities: a wake-up call to prevent avoidable deaths
Purpose of review To identify patterns and key issues though a systematic review in order to support prevention strategies and reduce avoidable deaths related to drug-induced anaphylaxis (DAF). Recent findings DAF rate has been estimated by 0.13–0.53/106 population/year. General global trends of DAF are increasing over time, mostly occurring at healthcare settings (62%) with a similar gender distribution and an average age of 53 years. Antibiotics, anaesthetics, radio-contrast media and NSAIDs were the most frequently implicated agents. Main comorbidities were personal history of drug allergy, cardiovascul...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Risk Factors for Immediate-Type Local Anesthetic Hypersensitivity Reactions in Pediatric Patients: A Retrospective Case-Control Study
Source: Journal of Asthma and Allergy - April 8, 2022 Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

A case of Perioperative Anaphylaxis Presenting as Hereditary Alpha Tryptasemia
A 64-year-old Caucasian male with a past medical history of hypertension, anxiety, arthritis, depression, and hyperlipidemia presented to the operating room (OR) for a planned shoulder graft surgery. He has had multiple prior surgeries without complications. Prior to the procedure he received a local nerve block with Lidocaine and Bupivacaine in the post anesthesia care unit (PACU). Afterwards he was transported to the OR where he received general anesthesia that included the following: Propofol, Cefazolin, Succinylcholine, Midazolam, Rocuronium, Fentanyl, and an inhaled anesthetic.
Source: Annals of Allergy, Asthma and Immunology - March 12, 2022 Category: Allergy & Immunology Authors: Shaunah Ritter, Jarred Bowden, Debendra Pattanaik Source Type: research

Molecular characterization of bronchoconstriction induced by activated T cells
Conclusions: T cell activation caused airflow limitation in addition to eosinophilic inflammation, AHR, and mucous hyperplasia. T cell-derived bronchoconstriction seems a good target for treatment-resistant asthma.
Source: European Respiratory Journal - November 25, 2021 Category: Respiratory Medicine Authors: Mori, A., Kouyama, S., Yamaguchi, M., Kumitani, C., Ohtomo-Abe, A., Kawasaki, Y., Iwamoto, K., Yano, K., Iwata, M., Nagayama, K., Ryu, K., Nakamura, Y., Hamada, Y., Watai, K., Kamide, Y., Sekiya, K., Fukutomi, Y., Ohtomo, T., Kaminuma, O. Tags: Allergy and immunology Source Type: research

M022 a case of perioperative anaphylaxis: high-risk drug allergy testing in the inpatient setting
As multiple medications are often administered simultaneously during anesthesia, determining the etiology of perioperative anaphylaxis is challenging. This is compounded by the lack of validated skin testing. While drug challenges are the definitive means of assessing for IgE-mediated drug allergy, they must be weighed with the risk for developing a severe reaction.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: E. Robbins, S. Gabryszewski, J. Cafone, J. Lee Source Type: research

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