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The Safety and Immunologic Effectiveness of the Live Varicella-Zoster Vaccine in Patients Receiving Tumor Necrosis Factor Inhibitor Therapy : A Randomized Controlled Trial
CONCLUSION: This trial informs safety concerns related to use of live virus vaccines in patients receiving biologics.PRIMARY FUNDING SOURCE: The National Institute of Arthritis and Musculoskeletal and Skin Diseases and the American College of Rheumatology.PMID:34570596 | DOI:10.7326/M20-6928
Source: Annals of Internal Medicine - September 27, 2021 Category: Internal Medicine Authors: Jeffrey R Curtis Stacey S Cofield S Louis Bridges John Bassler Atul Deodhar Theresa L Ford Joseph Huffstutter Allen Jankeel Alan Kivitz Shaila Kamal Stephen Lindsey Ilhem Messaoudi Norma Mendoza Kaleb Michaud Ted R Mikuls David Ridley William Shergy Sarah Source Type: research

Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Risk of herpes zoster with IL-17 inhibitor therapy for psoriasis and other inflammatory conditions.
Authors: Wu KK, Lee MP, Lee EB, Wu JJ Abstract Psoriasis is a chronic inflammatory skin disease that has been associated with a significantly higher risk of herpes zoster (HZ). Several newer biologics such as secukinumab, ixekizumab, and brodalumab inhibit IL-17 and have been highly effective for treatment of psoriasis. However, adverse events related to the immunosuppressive properties of these biologics have been observed. This review aims to synthesize and evaluate the literature investigating the risk of HZ in patients treated with IL-17 inhibitors, with a focus on psoriasis patients. Clinical trials, cohort st...
Source: Journal of Dermatological Treatment - March 24, 2019 Category: Dermatology Tags: J Dermatolog Treat Source Type: research

Interventions to improve vaccine acceptance among rheumatoid arthritis patients: a systematic review
ConclusionsInterventions to enhance vaccine uptake in RA focused almost exclusively on improving provider prescription of vaccines using reminder-type interventions. Although effective in improving vaccination rates, those studies used heterogeneous interventions and behavior change techniques. Few studies measured provider prescribing behavior as an outcome. Future studies targeting providers should measure relevant provided-related outcomes and their impact on patient outcomes, to determine overall efficacy.
Source: Clinical Rheumatology - January 15, 2019 Category: Rheumatology Source Type: research

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