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Current Clinical Trials in Pemphigus and Pemphigoid
Conclusions The clinical trials discussed here, which include several trials investigating novel therapeutic targets, demonstrate that translational research in pemphigus and pemphigoid is a fast-growing field. We thus expect that several novel treatments will be shortly available for the treatment of pemphigus and pemphigoid patients. Given the high, and thus far unmet, medical need in this field (110), this is highly encouraging and will hopefully improve the quality of life of the affected patients. In addition to the compounds and targets described here, several new targets have been recently identified in preclinical...
Source: Frontiers in Immunology - May 2, 2019 Category: Allergy & Immunology Source Type: research

Question 2: Should steroids be used in the treatment of septic arthritis?
Scenario You are the paediatric registrar on duty when a 12-year-old boy is admitted to your ward with a strong suspicion of septic arthritis of the left knee. He plays soccer at competitive level; the boy and his parents are concerned about the long-term consequences for his playing. While you are waiting for the result of the white count of the synovial fluid to confirm the diagnosis and promptly start antibiotic therapy, you remember a recent discussion about the use of steroids in infectious disease, and so you decide to review the literature and analyse whether the use of steroids as an adjuvant therapy could improve ...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Macchiaiolo, M., Buonuomo, P. S., Mennini, M., Villani, A., Bartuli, A. Tags: ADC Archimedes, Oncology, Football (soccer), Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Rheumatology, Trauma, Injury Source Type: research

Relevance of gad antibodies in adults with epilepsy: experience in a tertiary clinic
Conclusion Our experience suggests that GAD antibodies are present in a significant number of patients with adult onset epilepsy, especially those with other autoimmune disorders. The relevance of GAD antibodies in this setting remains unclear. The presence of OCBs and GAD antibodies within the CSF suggest a CNS based autoimmune process but the GAD antibodies themselves may be a marker of this processes rather than being directly pathogenic, as is suggested for antibodies directed against neuronal surface antigens. In our cohort immunotherapy did not improve seizure control and it may be that these antibodies are produced ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Lilleker, J., Biswas, V., Mohanraj, R. Tags: Immunology (including allergy), Brain stem / cerebellum, Cranial nerves, Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Ophthalmology, Radiology, Connective tissue disease, Musculoskeletal syndromes, Source Type: research