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Recurrent Membranoproliferative Glomerulonephritis After Kidney Transplantation: Risk Factors and Impact on Graft Survival
CONCLUSIONS The MPGN recurrence rate was 25%, most of them recipients of kidneys from living donors. Nephrotic syndrome and C3 consumption were frequent at recurrence. The graft function was similar between the groups, and the 5-year graft survival rate in the recurrence group was higher than in other studies.PMID:37461201 | PMC:PMC10362803 | DOI:10.12659/AOT.940502
Source: Annals of Transplantation - July 18, 2023 Category: Transplant Surgery Authors: Lais Ceccatto de Paula Marilda Mazzali Marcos Vinicius de Sousa Source Type: research

Role of cyclosporin A in the treatment of kidney disease and nephrotoxicity
Toxicology. 2023 May 8:153544. doi: 10.1016/j.tox.2023.153544. Online ahead of print.ABSTRACTThe clinical use of cyclosporin A (CsA) has led to significant advances and achievements in the field of transplantation and immune diseases. However, the nephrotoxicity of CsA is a major concern in current immunosuppression regimens. CsA causes abnormal kidney function while treating kidney disease, causing problems for clinicians and patients. Evidence of CsA nephrotoxicity is almost always present in transplant recipients after long-term CsA administration (up to 10 years), and similar phenomena occur with other calcineurin inhi...
Source: Toxicology - May 10, 2023 Category: Toxicology Authors: Jun Yu Xiao Wei Jinzhang Gao Chun Wang Wei Wei Source Type: research

Interventions for preventing and treating kidney disease in IgA vasculitis
CONCLUSIONS: There are no substantial changes in conclusions from this update compared with the initial review or the previous update despite the addition of five studies. From generally low to moderate certainty evidence, we found that there may be little or no benefit in the use of corticosteroids or antiplatelet agents to prevent persistent kidney disease in children with IgAV in participants with no or minimal kidney involvement at presentation. We did not find any studies which evaluated corticosteroids in children presenting with IgAV and nephritic and/or nephrotic syndrome, although corticosteroids are recommended i...
Source: Cochrane Database of Systematic Reviews - February 28, 2023 Category: General Medicine Authors: Deirdre Hahn Elisabeth M Hodson Jonathan C Craig Source Type: research

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