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Intersectoral management of patients with abnormal liver enzymes and non-alcoholic fatty liver disease (NAFLD)
Z Gastroenterol. 2023 Feb 15. doi: 10.1055/a-1957-5671. Online ahead of print.ABSTRACTThe prevalence of fatty liver disease has increased significantly in Germany in recent years. With an estimated 18 million German citizens being affected, it is now among the most prevalent diseases. Furthermore, it is also considered a relevant and independent risk factor for other common cardiovascular diseases such as heart attack or stroke. Finally, diabetes mellitus promotes the development of and an unfavorable course of fatty liver disease. Given the high prevalence and complications, the German healthcare system is reaching its li...
Source: Zeitschrift fur Gastroenterologie - February 15, 2023 Category: Gastroenterology Authors: Andreas Teufel Andreas Geier Christoph Sarrazin J örn M Schattenberg Achim Kautz Rebecca Dorner Jan Kramer Katrin Jerysiak Theodor Baars Bastian H önscheid Dirk M üller-Wieland Siegbert Rossol Christian Trautwein Frank Tacke Ali Canbay Source Type: research

Cardiovascular disease risk in paediatric and young adult non-alcoholic fatty liver disease
Conclusion Compared with matched population controls, children and young adults with biopsy-proven NAFLD had significantly higher rates of incident MACE, including ischaemic heart disease and congestive heart failure. Research to better characterise cardiovascular risk in children and young adults with NAFLD should be prioritised.
Source: Gut - February 7, 2023 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Alkhouri, N., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

NAFLD in Cardiovascular Diseases: A Contributor or Comorbidity?
In conclusion, a more comprehensive, multidisciplinary approach to diagnosis and management of patients with NAFLD and cardiovascular diseases is needed to optimize clinical outcomes. [...] Thieme Medical Publishers, Inc. 333 Seventh Avenue, 18th Floor, New York, NY 10001, USAArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Liver Disease - October 14, 2022 Category: Gastroenterology Authors: Chen, Bing Tang, W.H Wilson Rodriguez, Mario Corey, Kathleen E. Sanyal, Arun J. Kamath, Patrick S. Bozkurt, Biykem Virk, Hafeez Ul Hassan Pressman, Gregg S. Lazarus, Jeffrey V. El-Serag, Hashem B. Krittanawong, Chayakrit Tags: Review Article Source Type: research

Optimising the management of cardiovascular comorbidities in NAFLD patients: its time to (re-) act!
With great interest, we have read the recent article by Simon et al,1 reporting a significant association between non-alcoholic fatty liver disease (NAFLD) and incident major adverse cardiovascular events. The authors found that patients with biopsy-proven NAFLD had a significantly higher incidence of ischaemic heart disease, stroke, congestive heart failure and death due to cardiovascular disease (CVD), when compared with matched controls. An excess in CVD morbidity and mortality was evident across all stages of NAFLD and increased with worsening disease severity. The authors are to be congratulated for conducting such a ...
Source: Gut - October 7, 2022 Category: Gastroenterology Authors: Kasper, P., Lang, S., Demir, M., Steffen, H.-M. Tags: Gut PostScript Source Type: research

Non-alcoholic fatty liver disease and incident major adverse cardiovascular events: results from a nationwide histology cohort
Conclusion Compared with matched population controls, patients with biopsy-proven NAFLD had significantly higher incidence of MACE, including IHD, stroke, CHF and CV mortality. Excess risk was evident across all stages of NAFLD and increased with worsening disease severity.
Source: Gut - August 11, 2022 Category: Gastroenterology Authors: Simon, T. G., Roelstraete, B., Hagström, H., Sundström, J., Ludvigsson, J. F. Tags: Gut Hepatology Source Type: research

Complete alcohol abstinence increases the risk of NAFLD but not severity. A population analysis with transient elastography
CONCLUSION: Interestingly, modest alcohol consumption is associated with decreased odds of NAFLD. Further investigations are required to examine the relationship between alcohol consumption and NAFLD and subsequently the potential impact on NAFLD management.PMID:35944527 | DOI:10.1080/00365521.2022.2105168
Source: Scandinavian Journal of Gastroenterology - August 9, 2022 Category: Gastroenterology Authors: Jieling Xiao Cheng Han Ng Kai En Chan Ansel Shao Pin Tang Readon Teh Abel Ho Zhi Ling Jie Ning Yong Wen Hui Lim Darren Jun Hao Tan Caitlyn Tan Khin Maung Win Aung Hlaing Bwa Nicholas W S Chew Daniel Huang Yock Young Dan Mazen Noureddin Mohammad Shadab Sid Source Type: research

Does non-alcoholic fatty liver disease predispose patients to carotid arteriosclerosis and ischemic stroke?
Clin Mol Hepatol. 2022 Jun 22. doi: 10.3350/cmh.2022.0155. Online ahead of print.NO ABSTRACTPMID:35730209 | DOI:10.3350/cmh.2022.0155
Source: Clinical and molecular hepatology - June 22, 2022 Category: Gastroenterology Authors: Qian Jin Rui-Xu Yang Jian-Gao Fan Source Type: research

The Effect of Diabetes and Prediabetes on the Prevalence, Complications and Mortality in Non-alcoholic Fatty Liver Disease
CONCLUSION: Given the increased risk of adverse outcomes, this study highlights the importance of regular diabetes screening in NAFLD and adoption of prompt lifestyle modifications to reduce disease progression. Facing high cardiovascular burden, prediabetic and diabetic NAFLD individuals can benefit from early cardiovascular referrals to reduce risk of CVD events and mortality.PMID:35585687 | DOI:10.3350/cmh.2022.0096
Source: Clinical and molecular hepatology - May 19, 2022 Category: Gastroenterology Authors: Cheng Han Ng Kai En Chan Yip Han Chin Rebecca Wenling Zeng Pei Chen Tsai Wen Hui Lim Darren Jun Hao Tan Chin Meng Khoo Lay Hoon Goh Zheng Jye Ling Anand Kulkarni Lung-Yi Loey Mak Daniel Q Huang Mark Chan Nicholas Ws Chew Mohammad Shadab Siddiqui Arun J Sa Source Type: research

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