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Heart transplantation for COVID-19 myopathy in the United States
Evidence on characteristics and outcomes of patients undergoing heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy is limited to case reports. Of all 6332 patients aged ≥18 years undergoing heart transplant from July 2020 through May 2022 in the United Network for Organ Sharing database, 12 (0.2%) patients had COVID-19 myocarditis and 98 (1.6%) patients with the same level of care had non-COVID-19 myocarditis. Their median age was 49 (range 19-74) years. All pati ents were hospitalized in the intensive care unit and 92.7% (n=102) were on life support prior to transplantation.
Source: The Journal of Heart and Lung Transplantation - October 5, 2022 Category: Transplant Surgery Authors: George Gill, Amy Roach, Georgina Rowe, Dominic Emerson, Jon Kobashigawa, Errol P. Lobo, Fardad Esmailian, Michael E. Bowdish, Joanna Chikwe Tags: Brief Communication Source Type: research

Chloroquine- and Hydroxychloroquine-Induced Cardiomyopathy: A Case Report and Brief Literature Review.
CONCLUSION: CQ and HCQ myopathy can present following long-term administration of the drug. The pathologic findings are nonspecific and overlap with other vacuolated myopathies, necessitating careful correlation of the histologic changes with the patient's medical history. PMID: 33316045 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - December 14, 2020 Category: Pathology Authors: Nadeem U, Raafey M, Kim G, Treger J, Pytel P, N Husain A, Schulte JJ Tags: Am J Clin Pathol Source Type: research

A cross-sectional analysis of clinical evaluation in 35 individuals with mutations of the valosin-containing protein gene
Inclusion Body Myopathy (IBM) associated with Paget's disease of the bone (PDB) and/or frontotemporal dementia (FTD) or Multisystem Proteinopathy (OMIM 167320) or more commonly called IBMPFD or VCP disease, was first reported by Kimonis et al. (2000) [1]. VCP disease comprises other less common phenotypes including amyotrophic lateral sclerosis (ALS), Parkinson's disease, cardiomyopathy, sensory motor axonal neuropathy, and sphincter disturbance [2 –6]. IBMPFD is an underdiagnosed disease that has been reported in greater than 100 families worldwide, but is more commonly found in the United States and Europe.
Source: Neuromuscular Disorders - June 22, 2018 Category: Neurology Authors: Jake Plewa, Abhilasha Surampalli, Marie Wencel, Merit Milad, Sandra Donkervoort, Vincent J. Caiozzo, Namita Goyal, Tahseen Mozaffar, Virginia Kimonis Source Type: research

A Review of Mathematical Models for Muscular Dystrophy: A Systems Biology Approach
Discussion With new developments in computational power and data availability, a growing amount of research is using a systems biology approach to understand pathogenesis and progression of disease. Effective and integrated in vitro and in silico models could inform biological phenomena, even without the need of a living subject. For instance, over the last few decades, collagen hydrogel with muscle derived cells (CHMDCs) have promised to revolutionize in vitro experiments and tissue engineering. For CHMDCs to reach the envisioned use, verification by use of mathematical simulations are needed. Recently while examining sha...
Source: PLOS Currents Muscular Dystrophy - February 16, 2018 Category: Neurology Authors: Matthew Houston Source Type: research