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Total 2683 results found since Jan 2013.
Stimulator of interferon genes (STING): Key therapeutic targets in ischemia/reperfusion injury
Biomed Pharmacother. 2023 Sep 10;167:115458. doi: 10.1016/j.biopha.2023.115458. Online ahead of print.ABSTRACTThe Stimulator of Interferon Genes (STING) is predominantly expressed in immune cells, including macrophages, natural killer cells, dendritic cells, and T cells, functioning as a pattern recognition receptor. STING activation upon detecting cytosolic DNA released from damaged cells initiates downstream pathways, leading to the production of inflammatory cytokines such as IFNs, IL-6, and TNF-α. Dysregulated STING activation has been implicated in inflammatory and metabolic diseases. Ischemia/reperfusion injury (I/R...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 12, 2023 Category: Drugs & Pharmacology Authors: Juan Lv Xuanxuan Zhu Chunlei Xing Yuhong Chen Huihui Bian Heng Yin Xiaofeng Gu Li Su Source Type: research
Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges
J Autoimmun. 2023 Sep 8:103109. doi: 10.1016/j.jaut.2023.103109. Online ahead of print.ABSTRACTAutoimmune diseases (AIDs) are a series of immune-mediated lethal diseases featured by over-activated immune cells attacking healthy self-tissues and organs due to the loss of immune tolerance, which always causes severe irreversible systematical organ damage and threatens human health heavily. To date, there are still no definitive cures for the treatment of AIDs due to their pathogenesis has not been clearly understood. Besides, the current clinical treatments of AIDs majorly rely on glucocorticoids and immune suppressors, whic...
Source: Journal of Autoimmunity - September 10, 2023 Category: Allergy & Immunology Authors: Xiaomin Liu Mei Liu Ming Zhao Ping Li Changxing Gao Xinyu Fan Guangyan Cai Qianjin Lu Xiangmei Chen Source Type: research
COVID-19 in transplant recipients: Multicentric report of Mexican experience
CONCLUSIONS: Transplant recipients show a higher fatality rate and complications from SARS-CoV-2 infection; more studies are needed to identify prognostic factors and effective anti-SARS-CoV-2 therapies.PMID:37669570 | DOI:10.24875/ACM.21000113
Source: Archivos de Cardiologia de Mexico - September 5, 2023 Category: Cardiology Authors: M ónica Sánchez-Cárdenas Enzo V ásquez-Jiménez Ricardo I Vel ázquez-Silva Mario Vilatob á-Chapa Benjam ín Gómez-Navarro Lucio O S ánchez-Macías Jos é M Rodríguez-Chagolla Ignacio Garc ía-Juárez Severo M Abraham-Mancilla Luis E Morales-Buenr Source Type: research
