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Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors
ConclusionSCCs are innervated by trigeminal nerve endings in healthy turbinate tissue but not in NPs. SCCs express ACh receptors as well as choline acetyltransferase and, in the setting of a type 2 inflammatory environment, denervated SCCs dramatically expand with nicotinic stimulation.
Source: International Forum of Allergy and Rhinology - April 21, 2021 Category: Allergy & Immunology Authors: Jie Deng, Li Hui Tan, Michael A. Kohanski, David W. Kennedy, John V. Bosso, Nithin D. Adappa, James N. Palmer, Jianbo Shi, Noam A. Cohen Tags: ORIGINAL ARTICLE Source Type: research

Randomized controlled trial of steroid ‐soaked absorbable calcium alginate nasal packing following endoscopic sinus surgery
ConclusionsThis study demonstrated that steroid‐soaked, absorbable nasal packing can be used to enhance wound healing after endoscopic sinus surgery and to prevent polypoid changes in the nasal mucosa. Level of Evidence1b. Laryngoscope, 2017
Source: The Laryngoscope - September 22, 2017 Category: ENT & OMF Authors: Chi Sang Hwang, Salma Saud Sharhan, Bo Ra Kim, Soo In Kim, Jin Woong Kim, Hyung ‐Ju Cho, Joo‐Heon Yoon, Chang‐Hoon Kim Tags: Allergy/Rhinology Source Type: research

XXIV World Allergy Congress 2015
Table of Contents A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts Jae-Min Shin, Heung-Man Lee, Il-Ho Park A2 The efficacy of a 2-week course of oral steroid in the treatment of chronic spontaneous urticaria refractory to antihistamines Hyun-Sun Yoon, Gyeong Yul Park A3 The altered distribution of follicular t helper cells may predict a more pronounced clinical course of primary sjögren’s syndrome Margit Zeher A4 Betamethasone suppresses Th2 cell development induced by langerhans cell like dendr...
Source: World Allergy Organization Journal - April 18, 2016 Category: Allergy & Immunology Source Type: research

Evaluation of vitamin D levels in allergic fungal sinusitis, chronic rhinosinusitis, and chronic rhinosinusitis with polyposis
ConclusionSerum level of VD3 in patient with CRSwNP and AFRS is significantly lower than that of patients with CRSsNP and control subjects. Although these results do not imply a specific etiological or therapeutic relationship, VD3 levels may constitute an inexpensive prophylactic and cost‐effective option in the therapeutic armamentarium in the control of AFRS and CRSwNP, either by itself or as a synergistic agent with traditional agents.
Source: International Forum of Allergy and Rhinology - December 1, 2015 Category: Allergy & Immunology Authors: Badr El‐Din Mostafa, Mohammed Shehata Taha, Tarek Abdel Hamid, Azza Omran, Neema Lotfi Tags: ORIGINAL ARTICLE Source Type: research

TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients.
CONCLUSIONS: The expression of TMEM16A and MUC5AC are increased in CRSwNP, which might be a direct effect of Th2 cytokines present in the sinonasal mucosa in CRSwNP. Down-regulation of TMEM16A expression and MUC5AC secretion in HNPECs by T16Ainh-A01 indicates that TMEM16A might play an important role in mucin secretion in upper airway inflammatory diseases. PMID: 25749771 [PubMed - as supplied by publisher]
Source: Allergy, Asthma and Immunology Research - March 12, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Verapamil modulates interleukin‐5 and interleukin‐6 secretion in organotypic human sinonasal polyp explants
ConclusionAlthough the mechanism has yet to be fully understood, L‐type CCBs are capable of reducing inflammation in multiple tissues. Verapamil was specifically found to reduce airway goblet cell hyperplasia and eosinophilic infiltration in a murine asthma model. Our data support these findings suggesting that verapamil can modulate T‐helper cell type 2 (Th2)‐associated cytokine secretion in sinonasal polyp explants. This data points to a possible therapeutic role for CCBs in the management of CRSwNP.
Source: International Forum of Allergy and Rhinology - October 1, 2014 Category: Allergy & Immunology Authors: Benjamin S. Bleier, Armine Kocharyan, Amy Singleton, Xue Han Tags: ORIGINAL ARTICLE Source Type: research