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Antibody Responses to the Host Microbiome in Chronic Rhinosinusitis
ConclusionsCompared to healthy controls, CRS patient's serum samples showed significantly increased sero-reactivity to both bacterial and viral proteins, reflecting recent or current infection or active colonization. Significantly higher antibodies againstStaphylococcus aureus, Human metapneumovirus, Human herpesvirus 5, and Human herpesvirus 4 in CRS needs further study.This article is protected by copyright. All rights reserved
Source: International Forum of Allergy and Rhinology - December 12, 2022 Category: Allergy & Immunology Authors: Devyani Lal, Lusheng Song, Tripti Brar, Emily K. Cope, Paul Keim, Stacy Williams, Yunro Chung, Vel Murugan, Joshua LaBaer, D. Mitchell Magee Tags: Original Article Source Type: research

The seasonality of respiratory viruses in patients with chronic rhinosinusitis.
CONCLUSIONS: The pattern of respiratory virus seasonality found in nasal mucosa, polyps, and paranasal sinus samples in patients with CRS reinforces the possibility of asymptomatic respiratory viral infections. PMID: 25590310 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - January 1, 2015 Category: ENT & OMF Authors: Lima JT, Paula FE, Proença-Modena JL, Demarco RC, Buzatto GP, Saturno TH, Delcaro LS, Tamashiro E, Valera FC, Arruda E, Anselmo-Lima WT Tags: Am J Rhinol Allergy Source Type: research

Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis
Type 2 innate lymphoid cells (ILC2) were identified in 2010 and include natural helper cells, nuocytes, and innate type 2 helper cells. ILC2 do not express known T-cell, B-cell, or natural killer–cell lineage markers (lineage-negative) and produce large amounts of IL-5 and IL-13 in response to cytokines IL-33, IL-25, or both. Importantly, ILC2 have been shown to contribute to airway hyperresponsiveness and type 2 lung inflammatory responses in mice infected with influenza virus, and after challenge with multiple allergens including Alternaria, papain, house dust mite, and ovalbumin, suggesting a potential role for ILC2 i...
Source: Journal of Allergy and Clinical Immunology - November 7, 2013 Category: Allergy & Immunology Authors: Jinny E. Chang, Taylor A. Doherty, Rachel Baum, David Broide Tags: Letters to the Editor Source Type: research