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Transcriptomic analysis of cellular senescence signatures in severe asthma
Conclusions: Cellular senescence may be involved in the pathophysiology of severe asthma, particularly in patients with comorbid nasal polyps. Further studies are warranted to validate the causal relationships.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Song, W., Zounemat-Kermani, N., Guo, Y., Adcock, I., Chung, K. F. Tags: 05.03 - Allergy and immunology Source Type: research

Mepolizumab effectiveness and identification of super-responders in severe asthma
Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population. The Australian Mepolizumab Registry (AMR) was established with an aim to assess the use, effectiveness and safety of mepolizumab for severe eosinophilic asthma in Australia. Patients (n=309) with severe eosinophilic asthma (median age 60 years, 58% female) commenced mepolizumab. They had poor symptom control (median Asthma Control Questionnaire (ACQ)-5 score of 3.4), frequent exacerbations (media...
Source: European Respiratory Journal - May 20, 2020 Category: Respiratory Medicine Authors: Harvey, E. S., Langton, D., Katelaris, C., Stevens, S., Farah, C. S., Gillman, A., Harrington, J., Hew, M., Kritikos, V., Radhakrishna, N., Bardin, P., Peters, M., Reynolds, P. N., Upham, J. W., Baraket, M., Bowler, S., Bowden, J., Chien, J., Chung, L. P. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Loss-of-Function in SMAD4 Might Not Be Critical for Human Natural Killer Cell Responsiveness to TGF- β
This study was carried out in accordance with approval of the Melbourne Health and Walter and Eliza Hall Institute of Medical Research's Human Research Ethics Committee (approval number: 2013.081). All subjects gave written informed consent for participation and publication. Results and Discussion TGF-β signaling in NK cells is associated with: phosphorylation in SMAD2 and 3, inhibition of IL-15-induced metabolism/proliferation, simultaneous downregulation of CD44, CD49e, and Eomes, and upregulation of CD16 and CD49a expression (7, 10). SMAD family member 4 (SMAD4) belongs to the SMAD family of transcript...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research