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Condition: Alzheimer's
Nutrition: Zinc
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Total 270 results found since Jan 2013.
Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD?
Autophagy. 2023 Jul 23:1-7. doi: 10.1080/15548627.2023.2214960. Online ahead of print.ABSTRACTNearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent "neurological pandemic" urges the identification of environmental risk factors that are hopefully avoided to fight the disease. In 2022, strong evidence in mouse models incriminated defective lysosomal acidification and impairment of the autophagy pathway as modifiable risk factors for dementia. To date, the most prescribed lysosomotropic drugs a...
Source: Autophagy - July 24, 2023 Category: Cytology Authors: Sandy Giuliano Christopher Montemagno Marie-Angela Domdom Manon Teisseire Patrick Brest Daniel J Klionsky Paul Hofman Gilles Pag ès Baharia Mograbi Source Type: research
Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review
Environ Res. 2023 Jul 22:116722. doi: 10.1016/j.envres.2023.116722. Online ahead of print.ABSTRACTThe ageing population has been steadily increasing worldwide, leading to a higher risk of cognitive decline and dementia. Environmental toxicants, particularly metals, have been identified as modifiable risk factors for cognitive impairment. Continuous exposure to metals occurs mainly through dietary sources, with older adults being particularly vulnerable. However, imbalances in the gut microbiota, known as dysbiosis, have also been associated with dementia. A literature review was conducted to explore the potential role of m...
Source: Environmental Research - July 24, 2023 Category: Environmental Health Authors: David Mateo Montse Marqu ès Margarita Torrente Source Type: research
Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD?
Autophagy. 2023 Jul 23:1-7. doi: 10.1080/15548627.2023.2214960. Online ahead of print.ABSTRACTNearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent "neurological pandemic" urges the identification of environmental risk factors that are hopefully avoided to fight the disease. In 2022, strong evidence in mouse models incriminated defective lysosomal acidification and impairment of the autophagy pathway as modifiable risk factors for dementia. To date, the most prescribed lysosomotropic drugs a...
Source: Autophagy - July 24, 2023 Category: Cytology Authors: Sandy Giuliano Christopher Montemagno Marie-Angela Domdom Manon Teisseire Patrick Brest Daniel J Klionsky Paul Hofman Gilles Pag ès Baharia Mograbi Source Type: research
Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review
Environ Res. 2023 Jul 22:116722. doi: 10.1016/j.envres.2023.116722. Online ahead of print.ABSTRACTThe ageing population has been steadily increasing worldwide, leading to a higher risk of cognitive decline and dementia. Environmental toxicants, particularly metals, have been identified as modifiable risk factors for cognitive impairment. Continuous exposure to metals occurs mainly through dietary sources, with older adults being particularly vulnerable. However, imbalances in the gut microbiota, known as dysbiosis, have also been associated with dementia. A literature review was conducted to explore the potential role of m...
Source: Environmental Research - July 24, 2023 Category: Environmental Health Authors: David Mateo Montse Marqu ès Margarita Torrente Source Type: research
Should evidence of an autolysosomal de-acidification defect in Alzheimer and Parkinson diseases call for caution in prescribing chronic PPI and DMARD?
Autophagy. 2023 Jul 23:1-7. doi: 10.1080/15548627.2023.2214960. Online ahead of print.ABSTRACTNearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent "neurological pandemic" urges the identification of environmental risk factors that are hopefully avoided to fight the disease. In 2022, strong evidence in mouse models incriminated defective lysosomal acidification and impairment of the autophagy pathway as modifiable risk factors for dementia. To date, the most prescribed lysosomotropic drugs a...
Source: Autophagy - July 24, 2023 Category: Cytology Authors: Sandy Giuliano Christopher Montemagno Marie-Angela Domdom Manon Teisseire Patrick Brest Daniel J Klionsky Paul Hofman Gilles Pag ès Baharia Mograbi Source Type: research
The Biogenetic Synthesis of Metallic Nanoparticles and the Role They Play in Anti-inflammatory Drug Treatment
CONCLUSION: The current research focuses on metallic nanoparticles employed as anti-inflammatory medication molecules, although nanoparticles have applications in various areas (medicine, chemical engineering, and agriculture). Nanoparticles have a large surface-to-volume ratio, which can help them to penetrate cell membranes, and because of their solid ligand-binding capabilities, nanoparticles have been used in the medical treatment of inflammatory pathologies.PMID:37464822 | DOI:10.2174/1570163820666230718123544
Source: Current Drug Discovery Technologies - July 19, 2023 Category: Drugs & Pharmacology Authors: Meena Kurup Mohan Kumar Sambathkumar Ramanathan Margnat Chandra Source Type: research
Isotope dilution LA-ICP-MS for quantitative imaging of trace elements in mouse brain sections
In this study, we present a novel method for the quantitative imaging of trace elements (copper and zinc) in mouse brain sections using ID-LA-ICP-MS. We used an electrospray-based coating device (ECD) to evenly distribute a known amount of the spike (65Cu and 67Zn) on the sections. The optimal conditions for this process involved evenly distributing the enriched isotopes on mouse brain sections mounted on indium tin oxide (ITO) glass slides using the ECD with the 10 mg g-1 ɑ-cyano-4-hydroxycinnamic acid (CHCA) in methanol at 80 °C. The mass of the spiked isotopes and the tissue sections on the ITO slides was calculated b...
Source: Analytica Chimica Acta - July 9, 2023 Category: Chemistry Authors: Jinhui Liu Lingna Zheng Qian Li Liuxing Feng Bing Wang Mingli Chen Meng Wang Jianhua Wang Weiyue Feng Source Type: research
Revealing the amyloid β-protein with zinc finger protein of micronucleus during Alzheimer's disease progress by a quaternary ammonium terpyridine probe
Biosens Bioelectron. 2023 Jun 3;236:115446. doi: 10.1016/j.bios.2023.115446. Online ahead of print.ABSTRACTMicronucleus (MN) is regarded as an abnormal structure in eukaryotic cells which can be used as a biomarker for genetic instability. However, direct observation of MN in living cells is rarely achieved due to the lack of probes that are capable of distinguishing nuclear- and MN-DNA. Herein, a water-soluble terpyridine organic small molecule (ABT) was designed and employed to recognize Zinc-finger protein (ZF) for imaging intracellular MN. The in vitro experiments suggested ABT has a high affinity towards ZF. Further l...
Source: Biosensors and Bioelectronics - June 8, 2023 Category: Biotechnology Authors: Haitao Ding Shangke Liu Wei Du Liping Su Junyang Chen Yupeng Tian Dayi Pan Lei Chen Loris Rizzello Xiaowei Zheng Giuseppe Battaglia Kui Luo Qiyong Gong Xiaohe Tian Source Type: research
