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CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation,invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - November 19, 2017 Category: Pathology Source Type: research

CIP2A is overexpressed in human endometrioid adenocarcinoma and regulates cell proliferation, invasion and apoptosis
Conclusions CIP2A is overexpressed in endometrioid adenocarcinoma and CIP2A promotes the malignant growth and invasion,decrease apoptosis in entometrioid adenocarcinoma cell lines. These results validate that CIP2A plays an important role in the carcinogenesis of endometrioid adenocarcinoma and establishes CIP2A as a clinically relevant oncoprotein and may presents a promising therapeutic target for cancer treatment.
Source: Pathology Research and Practice - December 22, 2017 Category: Pathology Source Type: research

MiR‐506 inhibits multiple targets in the epithelial‐to‐mesenchymal transition network and is associated with good prognosis in epithelial ovarian cancer
In this study, we provide evidence that miR‐506 simultaneously suppresses vimentin and N‐cad. The knockdown of vimentin using siRNA reversed EMT, suppressed cell migration and invasion, and increased E‐cad expression on cell membrane in epithelial ovarian cancer (EOC) cells. In a set of tissue microarrays that included 204 EOCs of all major subtypes (e.g., serous, endometrioid, clear cell, and mucinous), miR‐506 was positively correlated with E‐cad and negatively correlated with vimentin and N‐cad in all subtypes of EOC. A high level of miR‐506 was positively associated with early FIGO stage and longer surviv...
Source: The Journal of Pathology - September 17, 2014 Category: Pathology Authors: Yan Sun, Limei Hu, Hong Zheng, Marina Bagnoli, Yuhong Guo, Rajesha Rupaimoole, Cristian Rodriguez‐Aguayo, Gabriel Lopez‐Berestein, Ping Ji, Kexin Chen, Anil K. Sood, Delia Mezzanzanica, Jinsong Liu, Baocun Sun, Wei Zhang Tags: Original Article Source Type: research

LncRNA HEIH Enhances Paclitaxel-Tolerance of Endometrial Cancer Cells via Activation of MAPK Signaling Pathway.
This study aimed to investigate the function of lncRNA HEIH on promoting endometrial cancer cells' tolerance of paclitaxel (PTX). LncRNA HEIH expression was measured by QRT-PCR in endometrial cancer tissues, human healthy tissues and cell lines. The PTX-resistant endometrial cancer cells (Ishikawa-RE and HHUA-RE) were intermittently exposed to increase concentrations of PTX and were constructed as evidenced by MTT assay. Besides, the specific siRNA of HEIH (siHEIH) and pcDNA3.1-HEIH plasmid transfection were utilized to alter the expression of HEIH in the cells and investigate the effects of HEIH on resistance to PTX in en...
Source: Pathology Oncology Research - October 23, 2019 Category: Pathology Authors: Guo JL, Tang T, Li JH, Yang YH, Zhang L, Quan Y Tags: Pathol Oncol Res Source Type: research