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Specialty: Chemistry
Cancer: Prostate Cancer
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Total 693 results found since Jan 2013.
The active phthalate metabolite, DHEP, induces proliferation and metastasis of prostate cancer cells via upregulation of β-catenin and downregulation of KLF7
Bioorg Chem. 2023 Sep 15;141:106864. doi: 10.1016/j.bioorg.2023.106864. Online ahead of print.ABSTRACTPhthalates such as DHEP are among the widely used compounds in industry. It has been shown that DHEP can convey various biological consequences in mammalian cells, among them, the carcinogenic effects of DHEP are emphasized. The present study aimed to assess the impact of DHEP exposure on the proliferation and invasiveness of DU145 prostate cancer cells through in vitro and in vivo models. The DU145 cells were treated with increasing concentrations of DHEP and the tumorigenic parameters were analyzed. KLF7 as a probable me...
Source: Bioorganic Chemistry - September 21, 2023 Category: Chemistry Authors: Hecheng Li Jianping Li Yubo Ma Ziming Wang Zihe Peng Hang Xu Hang Bi Shaik Althaf Hussain Zhaolun Li Source Type: research
Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR
This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.PMID:37694781 | DOI:10.2174/1389557523666230911141339
Source: Mini Reviews in Medicinal Chemistry - September 11, 2023 Category: Chemistry Authors: Manish Chaudhary Shubham Kumar Paranjeet Kaur Sanjeev Kumar Sahu Amit Mittal Source Type: research
Metabolic signature biomarkers for predicting the recurrence of urological cancers
This article critically reviews for the first time, to our knowledge, the promise of metabolomics-based approaches to identify metabolic signatures as candidate prognostic biomarkers to predict recurrences at the time of surgery in prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC). Dysregulations in the levels of several tumoral, circulating, and excreted metabolites have been reported in PCa patients experiencing recurrence within 1.5 to 8 years of follow-up. The combination of these metabolic biomarkers with clinical parameters (e.g., pathological T stage, Gleason score) has shown great potentia...
Source: International Journal of Clinical Chemistry - September 10, 2023 Category: Chemistry Authors: Filipa Amaro M árcia Carvalho Maria de Lourdes Bastos Paula Guedes de Pinho Joana Pinto Source Type: research
Integrated transcriptome and proteome analysis indicates potential biomarkers of prostate cancer in offspring of pregnant rats exposed to a phthalate mixture during gestation and lactation
Chemosphere. 2023 Sep 8:140020. doi: 10.1016/j.chemosphere.2023.140020. Online ahead of print.ABSTRACTAs the second leading cause of death for cancer among men worldwide, prostate cancer (PCa) prevention and detection remain a critical challenge. One aspect of PCa research is the identification of common environmental agents that may increase the risk of initiation and progression of PCa. Endocrine disrupting chemicals (EDCs) are strong candidates for risk factors, partially because they alter essential pathways for prostate gland development and oncogenesis. Phthalates correspond to a set of commercially used plasticizers...
Source: Chemosphere - September 10, 2023 Category: Chemistry Authors: A M Aquino L G Alonso-Costa Santos Saa V A Rocha L F Barbisan A Bedrat L A Justulin J A Flaws B Lemos W R Scarano Source Type: research
Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy
In this study, the PROTAC strategy was used to perform structural modifications of the flavonoid derivative LWT-111 to design a series of flavonoid-based CDK9 degraders. Notably, compound CP-07 emerged as a potent CDK9 degrader, effectively suppressing the proliferation and colony formation of 22RV1 cells by downregulating Mcl-1 and c-Myc. Moreover, CP-07 exhibited significant tumor growth inhibition with a TGI of 75.1% when administered at a dose of 20 mg/kg in the 22RV1 xenograft tumor model. These findings demonstrated the potential of CP-07 as a powerful flavonoid-based CDK9 degrader for prostate cancer therapy.PMID:37...
Source: European Journal of Medicinal Chemistry - September 6, 2023 Category: Chemistry Authors: Tizhi Wu Zhiming Zhang Guangyue Gong Zekun Du Yifan Xu Sixian Yu Feihai Ma Xuan Zhang Yuxiao Wang Haoming Chen Shiqi Wu Xi Xu Zhixia Qiu Zhiyu Li Hongxi Wu Jinlei Bian Jubo Wang Source Type: research
Design, synthesis, and evaluation of a mitoxantrone probe (MXP) for biological studies
Bioorg Med Chem Lett. 2023 Sep 3:129465. doi: 10.1016/j.bmcl.2023.129465. Online ahead of print.ABSTRACTMitoxantrone (MX) is a robust chemotherapeutic with well-characterized applications in treating certain leukemias and advanced breast and prostate cancers. The canonical mechanism of action associated with MX is its ability to intercalate DNA and inhibit topoisomerase II, giving it the designation of a topoisomerase II poison. Years after FDA approval, investigations have unveiled novel protein-binding partners, such as methyl-CpG-binding domain protein (MBD2), PIM1 serine/threonine kinase, RAD52, and others that may con...
Source: Bioorganic and Medicinal Chemistry Letters - September 5, 2023 Category: Chemistry Authors: Savanna Wallin Sarbjit Singh Gloria E O Borgstahl Amarnath Natarajan Source Type: research
Differentiation of patients with and without prostate cancer using urine < sup > 1 < /sup > H NMR metabolomics
Magn Reson Chem. 2023 Sep 1. doi: 10.1002/mrc.5391. Online ahead of print.ABSTRACTProstate cancer (PCa) is one of the most prevalent cancers in men worldwide. For its detection, serum prostate-specific antigen (PSA) screening is commonly used, despite its lack of specificity, high false positive rate, and inability to discriminate indolent from aggressive PCa. Following increases in serum PSA levels, clinicians often conduct prostate biopsies with or without advanced imaging. Nuclear magnetic resonance (NMR)-based metabolomics has proven to be promising for advancing early-detection and elucidation of disease progression, ...
Source: Magnetic Resonance in Chemistry : MRC - September 1, 2023 Category: Chemistry Authors: Anna-Laura Hasubek Xiaoyu Wang Ella Zhang Marta Kobus Jiashang Chen Lindsey A Vandergrift Annika Kurreck Felix Ehret Sarah Dinges Annika Hohm Marlon Tilgner Alexander Buko Piet Habbel Johannes Nowak Nathaniel D Mercaldo Andrew Gusev Adam S Feldman Leo L C Source Type: research
