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Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells
Conclusions: Our results suggest that the extracts of this polyherbal combination increase histone 3 acetylation, inhibit the expression of class I and class II histone deacetylases, increase the activation of CBP/p300 and inhibit cell proliferation, in part, by up regulating p21 expression.
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: E-Chu HuangYi ZhaoGuoxun ChenSeung Joon BaekMichael F McEnteeSteven MinkinJohn P BiggerstaffJay Whelan Source Type: research

β‐Caryophyllene oxide Inhibits Constitutive and Inducible STAT3 Signaling Pathway Through Induction of the SHP‐1 Protein Tyrosine Phosphatase
Abstract Constitutive activation of STAT3 is frequently observed and closely linked with proliferation, survival, invasion, metastasis and angiogenesis in tumor cells. In the present study, we investigated whether β‐caryophyllene oxide (CPO), a sesquiterpene isolated primarily from the essential oils of medicinal plants such as guava (Psidium guajava), and oregano (Origanum vulgare L.), can mediate its effect through interference with the STAT3 activation pathway in cancer cells. The effect of CPO on STAT3 activation, associated protein kinases and phosphatase, STAT3‐regulated gene products and apoptosis was investiga...
Source: Molecular Carcinogenesis - June 13, 2013 Category: Molecular Biology Authors: Chulwon Kim, Somi K. Cho, Shweta Kapoor, Ansu Kumar, Shireen Vali, Taher Abbasi, Sung‐Hoon Kim, Gautam Sethi, Kwang Seok Ahn Tags: Research Article Source Type: research

Abstract 1255: The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells
Conclusion: Rosemary induces ER stress-mediated apoptotic cell death in prostate cancer cell lines, 22Rv1and LNCaP cells, leading to disruption of AR expression. Our data suggests that this Mediterranean dietary phytochemical possess strong anticancer activity and should be evaluated further as potential chemopreventive and/or chemotherapeutic agent for controlling prostate cancer. Citation Format: Sakina M. Petiwala, Saba Berhe, Gongbo Li, Angela G. Puthenveetil, Larisa Nonn, Jeremy J. Johnson. The Mediterranean herb rosemary modulates ER stress proteins to promote androgen receptor degradation in prostate cancer cells. [...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Petiwala, S. M., Berhe, S., Li, G., Puthenveetil, A. G., Nonn, L., Johnson, J. J. Tags: Prevention Research Source Type: research

Abstract 4110: Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis
Conclusions: Our study demonstrated that gartanin inhibited proliferation and induced apoptosis on prostate cancer cells in vitro. It achieves its anticancer effects partly through inhibiting AR and promoting ER stress. The ability of gartanin to inhibit prostate cancer cells suggests further research is needed to evaluate gartanin as a novel agent for the management of prostate cancer. Citation Format: Gongbo Li, Sakina Petiwala, Jeremy Johnson. Gartanin from the mangosteen fruit modulates androgen receptor and ER stress proteins in prostate cancer cells leading to apoptosis. [abstract]. In: Proceedings of the 105th Annua...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Li, G., Petiwala, S., Johnson, J. Tags: Prevention Research Source Type: research

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK
The objective in this study was to determine if the antiproliferative effects are mediated, in part, through the activation of AMPK signalling and inhibition of its downstream targets, lipogenesis and mTORC1 complex. By increasing the phosphorylation of AMPK in CWR22Rv1 and PC3 prostate cancer cell lines, Zyflamend decreased de novo lipid biosynthesis by decreasing the activity of acetyl-CoA carboxylase and the expressions of fatty acid synthase and SREBP-1c, with a concomitant up regulation of fatty acid oxidation. In addition, via AMPK, Zyflamend inhibited the activity of mTORC1 complex by directly phosphorylating raptor...
Source: Journal of Functional Foods - July 25, 2015 Category: Nutrition Source Type: research

Leonurine suppresses prostate cancer growth < em > in vitro < /em > and < em > in vivo < /em > by regulating miR-18a-5p/SLC40A1 axis
This study further unveiled the mechanism by which Leo inhibited prostate cancer progression, which provides a promising potential for its future clinical application.PMID:36588358 | DOI:10.4103/0304-4920.365459
Source: The Chinese Journal of Physiology - January 2, 2023 Category: Physiology Authors: Bin Liang Shouxi Cui Songnian Zou Source Type: research

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