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Cancer: Lung Cancer
Drug: Acetic Acid
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Total 23 results found since Jan 2013.
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell
Gut Microbes. 2023 Dec;15(2):2249143. doi: 10.1080/19490976.2023.2249143.ABSTRACTRecent studies have demonstrated that the antitumor immunity of immune cells can be modulated by gut microbiota and their metabolites. However, the underlying mechanisms remain unclear. Here, we showed that the serum butyric acid level is positively correlated with the expression of programmed cell death-1 (PD-1) on circulating CD8+ and Vγ9 Vδ2 (Vδ2+) T cells in patients with non-small cell lung cancer (NSCLC). Responder NSCLC patients exhibited higher levels of serum acetic acid, propionic acid, and butyric acid than non-responders. Deplet...
Source: Cancer Control - August 28, 2023 Category: Cancer & Oncology Authors: Xinhai Zhu Ke Li Guichao Liu Ruan Wu Yan Zhang Siying Wang Meng Xu Ligong Lu Peng Li Source Type: research
Cytotoxicity, antinociceptive and gastroproiltective potential of the Abuta selloana Eichler: a fruit plant from Catarinense flora, Brazil
In conclusion, A. selloana had interesting biological activities; presenting the leaves as a promising source for compounds with cytotoxic potential, however, further studies should be performed to confirm its antitumoral activity. Besides, the whole plant can be an important source of bioactive compounds associated with gastroprotective and antinociceptive properties.PMID:36228215 | DOI:10.1590/0001-3765202220210145
Source: An Acad Bras Cienc - October 13, 2022 Category: Science Authors: Luciane A N Nesello Adriana Campos Andr éa Rebello Francielli T Motta Luisa N B Mariano F átima C Buzzi Ana L úcia T G Ruiz Jo ão Ernesto DE Carvalho Valdir Cechinel-Filho Luisa M Silva Source Type: research
Acetic Acid Mediated for One-Pot Synthesis of Novel Pyrazolyl < em > s < /em > -Triazine Derivatives for the Targeted Therapy of Triple-Negative Breast Tumor Cells (MDA-MB-231) < em > via < /em > EGFR/PI3K/AKT/mTOR Signaling Cascades
Pharmaceutics. 2022 Jul 27;14(8):1558. doi: 10.3390/pharmaceutics14081558.ABSTRACTHere, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5,5-dimethyl-1,3-cyclohexadione or 1,3-cyclohexadionone) with N,N-dimethylformamide dimethylacetal, followed by addition of 2-hydrazinyl-4,6-disubstituted-s-triazine either in ethanol-acetic acid or neat acetic acid to afford a novel pyrazole and pyrazole-fused cycloalkanone systems. The synthetic protocol proved to be efficient, with a shorter reaction time and high chemical y...
Source: Cancer Control - August 26, 2022 Category: Cancer & Oncology Authors: Ihab Shawish Assem Barakat Ali Aldalbahi Walhan Alshaer Fadwa Daoud Dana A Alqudah Mazhar Al Zoubi Ma'mon M Hatmal Mohamed S Nafie Matti Haukka Anamika Sharma Beatriz G de la Torre Fernando Albericio Ayman El-Faham Source Type: research
Primary Tumor Suppression and Systemic Immune Activation of Macrophages through the Sting Pathway in Metastatic Skin Tumor
CONCLUSION: The abscopal effect of DMXAA treatment on the skin strongly reduced the spread of EML4-ALK lung cancer and CT26 colon cancer through the STING pathway and induced the presentation of antigens.PMID:34913283 | DOI:10.3349/ymj.2022.63.1.42
Source: Yonsei Medical Journal - December 16, 2021 Category: Universities & Medical Training Authors: Chun-Bong Synn Dong Kwon Kim Jae Hwan Kim Youngseon Byeon Young Seob Kim Mi Ran Yun Ji Min Lee Wongeun Lee Eun Ji Lee Seul Lee You-Won Lee Doo Jae Lee Hyun-Woo Kim Chang Gon Kim Min Hee Hong June Dong Park Sun Min Lim Kyoung-Ho Pyo Source Type: research
