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Allergen immunotherapy, cancer, and immune disorders
Purpose of review The purpose of this review is to provide an update on the intriguing relationships between allergies, allergen immunotherapy, cancer, and immune disorders. Allergic diseases and cancer are increasing in incidence and prevalence and a potential relationship, or not, between these diseases have been suggested for many years. Recent findings Recent findings suggest that there may be some causative effects between certain types of cancer and allergic diseases, as described in the text. Some types of cancer may be more linked to the presence of an allergic disease, than others. However, epigenetic f...
Source: Current Opinion in Allergy and Clinical Immunology - November 4, 2022 Category: Allergy & Immunology Tags: IMMUNOTHERAPY AND NEW TREATMENTS: Edited by Giovanni Passalacqua and Robert Bush Source Type: research

Cancers, Vol. 11, Pages 404: Allergic Signs in Glioma Pathology: Current Knowledge and Future Perspectives
aro Historically restrained to immune defense against parasite infections, allergic inflammation has been recently rediscovered to protect from a wide array of environmental triggers, such as xenobiotics and carcinogens, which can induce DNA damage and ultimately lead to cancer development. Moreover, cells and mediators typical of allergic responses can importantly modulate the tissue inflammatory milieu, which represents a crucial gatekeeper towards the acquisition of malignancy by cancer cells through immune escape. Numerous studies have described an inverse association between allergies and glioma development. Mast ...
Source: Cancers - March 21, 2019 Category: Cancer & Oncology Authors: Massimo Costanza Gaetano Finocchiaro Tags: Review Source Type: research

Consensus on Allergies and Glioma
Conclusion: A substantial amount of data on the inverse association between atopic conditions and glioma has accumulated, and findings from the GICC study further strengthen the existing evidence that the relationship between atopy and glioma is unlikely to be coincidental. Impact: As the literature approaches a consensus on the impact of allergies in glioma risk, future research can begin to shift focus to what the underlying biologic mechanism behind this association may be, which could, in turn, yield new opportunities for immunotherapy or cancer prevention. Cancer Epidemiol Biomarkers Prev; 25(2); 282–90. ©2016 AACR.
Source: Cancer Epidemiology Biomarkers and Prevention - February 4, 2016 Category: Cancer & Oncology Authors: Amirian, E. S., Zhou, R., Wrensch, M. R., Olson, S. H., Scheurer, M. E., Il'yasova, D., Lachance, D., Armstrong, G. N., McCoy, L. S., Lau, C. C., Claus, E. B., Barnholtz-Sloan, J. S., Schildkraut, J., Ali-Osman, F., Sadetzki, S., Johansen, C., Houlston, R Tags: Research Articles Source Type: research