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Targeted paclitaxel prodrug nanoassemblies to improve therapeutic effects for liver cancer
Colloids Surf B Biointerfaces. 2023 Mar 30;226:113285. doi: 10.1016/j.colsurfb.2023.113285. Online ahead of print.ABSTRACTProdrug nanoassemblies fabricated by anticancer drug conjugates exhibited more advantages in controlled drug release and bioavailability and favorable antitumor efficacy. In this paper, lactobionic acid (LA) was connected with polyethylene glycol through amido linkages, and paclitaxel was joined with polyethylene glycol by means of ester bonds to form the prodrug copolymer LA-PEG-PTX. Then, LA-PEG-PTX was automatically assembled into LA-PEG-PTX nanoparticles (LPP NPs) by dialysis. The LPP NPs had a rela...
Source: Cancer Control - April 7, 2023 Category: Cancer & Oncology Authors: Shasha Qin Jiamin Li Zhiling Pan Can Wang Bing-Feng Zhang Source Type: research

Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma
CONCLUSION: Liposomes co-loaded with ursolic acid and ginsenoside Rg3 could affect cell proliferation, apoptosis and cell cycle, thus slowing down the in vitro drug release ability of HCC.PMID:34730903 | DOI:10.18388/abp.2020_5608
Source: Acta Biochim Pol - November 3, 2021 Category: Biochemistry Authors: Bin Wang Qiaoqiao Xu Chenjian Zhou Yu Lin Source Type: research

Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges
This study summarized the possible causes of the high comorbidity of HCC and renal dysfunction. The possible mechanisms of CKD causing HCC involve uremia itself, long-term dialysis status, immunosuppressive agents for postrenal transplant status, and miscellaneous factors such as hormone alterations and dysbiosis. The possible mechanisms of HCC affecting renal function include direct tumor invasion and hepatorenal syndrome. Finally, we categorized the risk factors that could lead to both HCC and CKD into four categories: Environmental toxins, viral hepatitis, metabolic syndrome, and vasoactive factors. Both CKD and ESRD ha...
Source: World Journal of Gastroenterology : WJG - July 30, 2021 Category: Gastroenterology Authors: Hsuan Yeh Chung-Cheng Chiang Tzung-Hai Yen Source Type: research

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