Filtered By:
Specialty: Pathology
Cancer: Adenocarcinoma
This page shows you your search results in order of date.
Order by Relevance | Date
Total 2308 results found since Jan 2013.
RNF152 Suppresses Fatty Acid Oxidation and Metastasis of Lung Adenocarcinoma by Inhibiting IRAK1-Mediated AKR1B10 Expression
This study aimed to identify the role of ring finger protein 152 (RNF152) in LUAD. RNF152 was down-regulated in LUAD, and low RNF152 expression correlated with a poor prognosis in LUAD patients. RNF152 overexpression inhibited the proliferation and malignant phenotype of LUAD cells, whereas RNF152 knockdown exerted an opposite effect. Tumor cells overexpressing RNF152 showed less fatty acid oxidation compared with control cells, whereas RNF152 knockdown induced fatty acid uptake and oxidation. Further analysis revealed the binding reaction between RNF152 and interleukin-1 receptor-associated kinase 1 (IRAK1). RNF152 reduce...
Source: Am J Pathol - September 17, 2023 Category: Pathology Authors: Dengyan Zhu Yunfei Nie Yang Zhao Xiaoming Chen Zhichang Yang Yang Yang Source Type: research
Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research
Enteritis cystica profunda
We reported the case of a 45-year-old female, suffering from a Crohn's disease, with a Koenig's syndrome, diarrhea, abdominal pain and weight loss. The colonoscopy and the abdominopelvic scan showed a terminal ileal stenosis, with parietal calcifications. A surgical ileocecal resection was decided. Gross examination of the ileocecal resection showed a thickening of the ileal wall, with many mucin-filled cysts measuring 1mm to 2cm, with some calcifications. The ileal mucosa was ulcerated, and showed a stenotic sector extending over 3cm. Histological examination showed acute ulcerated ileitis lesions, with chronic ileitis le...
Source: Annales de Pathologie - August 27, 2023 Category: Pathology Authors: Axel Dr éau Cl émence Barthomeuf Marion Balesdent Mathurin Fumery Charles Sabbagh Denis Chatelain Source Type: research
MiR-375 promotes cisplatin sensitivity of lung adenocarcinoma
CONCLUSION: Overall, this study provides new insights into the role of miR-375 in the cisplatin sensitivity of LUAD. Our present findings may serve as a theoretical basis for new therapeutic strategies and predictive models of cisplatin resistance in LUAD.PMID:37625279 | DOI:10.1016/j.prp.2023.154765
Source: Pathology, Research and Practice - August 25, 2023 Category: Pathology Authors: Shuomeng Du Han Qu Ying Zhang Shihao Zhu Yang Wang Shuopeng Zhang Zhao Wang Qian Yang Songbin Fu Kexian Dong Source Type: research
Gene expression analysis of SOCS, STAT and PIAS genes in lung cancer patients
Pathol Res Pract. 2023 Aug 10;249:154760. doi: 10.1016/j.prp.2023.154760. Online ahead of print.ABSTRACTOne of the most devastating diseases with the highest prevalence and mortality rate worldwide is lung cancer. Non-small cell lung cancer (NSCLC) is the subtype of lung cancer in 85% of cases. In this work, the expression levels of the STAT, SOCS and PIAS family genes involved in angiogenesis, proliferation and differentiation were examined. Using QRT-PCR technique, the expression level of STAT3 gene was assessed and tumor tissue samples had higher expression than normal tissue. In addition, the histological grade of aden...
Source: Pathology, Research and Practice - August 16, 2023 Category: Pathology Authors: Solmaz Abolghasemi Maryam Bikhof Torbati Parviz Pakzad Soudeh Ghafouri-Fard Source Type: research
TFAP2A activates HMGA1 to promote glycolysis and lung adenocarcinoma progression
CONCLUSION: TFAP2A promotes glycolysis, proliferation and hampers apoptosis of LUAD cells by stimulating HMGA1. Hence, TFAP2A/HMGA1 may be a feasible therapeutic target for LUAD.AVAILABILITY OF DATA AND MATERIALS: All the data within this manuscript could be gotten from corresponding author at reasonable request.PMID:37586214 | DOI:10.1016/j.prp.2023.154759
Source: Pathology, Research and Practice - August 16, 2023 Category: Pathology Authors: Junjie Zhao Gang Lan Source Type: research
