• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Knockdown of NF- κB activating protein promotes pancreatic cancer growth and metastasis through mTOR signaling pathway
CONCLUSIONS: NKAP as an oncogene regulates the development of PAAD cells. The research found that the mTOR signaling pathway is engaged in the oncogenic role of NKAP in PAAD for the first time.PMID:37486443 | DOI:10.1007/s11033-023-08665-1
Source: Mol Biol Cell - July 24, 2023 Category: Molecular Biology Authors: Xiangrong Xu Danyang Hou Yujie Wang Jing Zhang Yu Hei Bobo Wang Shuyue Tian Yunqing Zhang Fenghui Wang Source Type: research

Tumor and stroma COL8A1 secretion induces autocrine and paracrine progression signaling in pancreatic ductal adenocarcinoma
Matrix Biol. 2022 Nov 11:S0945-053X(22)00134-2. doi: 10.1016/j.matbio.2022.11.002. Online ahead of print.ABSTRACTSeveral collagen subtypes are involved in pancreatic ductal adenocarcinoma (PDAC) desmoplasia, which constrains therapeutic efficacy. We evaluated collagen type VIII alpha 1 chain (COL8A1), whose function in PDAC is currently unknown. We identified COL8A1 expression in 7 examined PDAC cell lines by microarray analysis, western blotting, and RT‒qPCR. Higher COL8A1 expression occurred in 2 gemcitabine-resistant PDAC cell lines; pancreas tissue (n=15) from LSL-KrasG12D/+; Pdx-1-Cre mice with advanced PDAC predisp...
Source: Matrix Biology - November 14, 2022 Category: Molecular Biology Authors: Bin Yan Li Liu Lian Zhao Ulf Hinz Yiqiao Luo Xuefeng An Jury Gladkich Carolina de la Torre Zhenhua Huang Daniel Schrapel Wolfgang Gross Franco Fortunato Michael Sch äfer Matthias M Gaida Ingrid Herr Source Type: research

Upregulation of dual-specificity phosphatase-26 is required for transforming growth factor β1(TGFβ1)-induced Epithelial-mesenchymal transition in A549 and PANC1 cells
CONCLUSIONS: Data provided suggest that TGFβ1 modulates the expression of DUSP genes and that upregulation of DUSP26 may be required for TGFβ1-promoted EMT in A549 and PANC1 cells. Further studies should be carried out to elucidate the requirement of individual DUSPs in TGFβ1-associated EMT in tumor cells.PMID:36053282 | DOI:10.1007/s11033-022-07893-1
Source: Molecular Biology Reports - September 2, 2022 Category: Molecular Biology Authors: Sabire Guler Berrin Zik Abdullah Yalcin Source Type: research

The prognostic value of N6-methyladenosine RBM15 regulators in lung adenocarcinoma
Cell Mol Biol (Noisy-le-grand). 2022 May 22;68(1):130-139. doi: 10.14715/cmb/2022.68.1.17.ABSTRACTN6-methyladenosine (m6A) is the most common internal modification in mammalian mRNAs while RNA-binding motif protein 15 (RBM15) is an important methyltransferase in m6A modification. Increasing evidences have shown that RBM15 has a close correlation with lung cancer. However, specific functions of RBM15 in lung adenocarcinoma (LUAD) are limited. RBM15 expression was analyzed in human LUAD tissues and matched healthy lung tissue. RBM15 was knocked down via siRNA in A549 and H1734 cells. The relationships between RBM15 with cell...
Source: Cellular and Molecular Biology - July 9, 2022 Category: Molecular Biology Authors: Mingsheng Ma Wei Wang Biying Wang Yichen Yang Yunchao Huang Guangqiang Zhao Lianhua Ye Source Type: research

Pages: 1  2  3  4  5