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Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca2+ in FLO cells, an increase that is blocked by Ca2+-free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of intrac...
Source: AJP: Gastrointestinal and Liver Physiology - May 15, 2014 Category: Gastroenterology Authors: Li, D., Cao, W. Tags: CANCER BIOLOGY Source Type: research

934 Immune Factors Involved in the Promotion of Esophageal Adenocarcinoma As Defined by siRNA Library Screening
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Fiona Behan, Shane P. Duggan, Catherine Garry, Sinead Phipps, Dermot Kelleher Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Role Of Intracellular Calcium And NADPH Oxidase NOX5-S In Acid-Induced DNA Damage In Barrett's cells and Barrett's Esophageal Adenocarcinoma Cells.
In this study we examined the role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in a Barrett's EA cell line FLO and a Barrett's cell line CP-A. We found that pulsed acid treatment significantly increased tail moment in FLO and CP-A cells and histone H2AX phosphorylation in FLO cells. In addition, acid treatment significantly increased intracellular Ca(2+) in FLO cells, an increase which is blocked by Ca(2+) free medium with EGTA and thapsigargin. Acid-induced increase in tail moment was significantly decreased by NADPH oxidase inhibitor diphenylene iodonium in FLO cells, and by blockade of i...
Source: Am J Physiol Gastroi... - April 3, 2014 Category: Gastroenterology Authors: Li D, Cao W Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research

Expression of bile acid receptor TGR5 in gastric adenocarcinoma
In this study, we determined the expression of TGR5 in gastric adenocarcinoma and examined the role of TGR5 in cell proliferation. Strong TGR5 staining was present in 12% of cases of intestinal metaplasia but in no cases of normal gastric epithelium (P < 0.01). Moderate to strong TGR5 membranous and cytoplasmic staining was present in 52% of the intestinal but in only 25% of the diffuse subtype of adenocarcinomas (P < 0.001). Kaplan-Meier univariate survival analysis revealed that moderate to strong TGR5 staining was associated with decreased patient survival (P < 0.05). Treatment with taurodeoxycholic acid (TDCA,...
Source: AJP: Gastrointestinal and Liver Physiology - February 15, 2013 Category: Gastroenterology Authors: Cao, W., Tian, W., Hong, J., Li, D., Tavares, R., Noble, L., Moss, S. F., Resnick, M. B. Tags: CALL FOR PAPERS Source Type: research

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