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Gemcitabine and Erlotinib with or without Oxaliplatin in Previously Untreated Advanced Pancreatic Cancer: A Randomized Phase II Trial
CONCLUSION: The addition of oxaliplatin to a first-line gemcitabine/erlotinib regimen demonstrated higher response rates and significantly improved PFS in patients with locally advanced or metastatic pancreatic cancer.PMID:34296544 | PMC:PMC8298866 | DOI:10.3349/ymj.2021.62.8.671
Source: Yonsei Medical Journal - July 23, 2021 Category: Universities & Medical Training Authors: Sung Hee Lim Jina Yun Min Young Lee Han Jo Kim Kyoung Ha Kim Se Hyung Kim Sang Chul Lee Sang Byung Bae Chan Kyu Kim Namsu Lee Kyu Taek Lee Seong Kyu Park Yun Nah Lee Jong Ho Moon Source Type: research

Pathology and Molecular Characteristics of Pancreatic Cancer
This article focuses on the molecular and pathology alterations in PDAC.PMID:34511185 | PMC:PMC8442745 | DOI:10.1016/j.soc.2021.06.003
Source: The Medical Clinics of North America - September 13, 2021 Category: General Medicine Authors: Joseph F Kearney Volkan Adsay Jen Jen Yeh Source Type: research

Hemophagocytic lymphohistiocytosis due to pembrolizumab therapy for adenocarcinoma of the lung
Proc (Bayl Univ Med Cent). 2021 Jul 14;34(6):729-730. doi: 10.1080/08998280.2021.1945353. eCollection 2021.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare disorder of dysregulated inflammation. It is most commonly seen in children who have a predisposing genetic mutation. However, adults can contract an acquired version of the disorder secondary to an infectious, neoplastic, or other inflammatory insult. There have been several documented cases of HLH being induced by treatment with immunotherapy. Here, we present the case of a 71-year-old man who was receiving pembrolizumab for lung adenocarcinoma when he devel...
Source: Baylor University Medical Center Proceedings - November 4, 2021 Category: Universities & Medical Training Authors: James J Doyle James A Hall Kelsey Reely Jyothi Dodlapati Source Type: research