Filtered By:
Specialty: Drugs & Pharmacology
Cancer: Brain Cancers
This page shows you your search results in order of date.
Order by Relevance | Date
Total 856 results found since Jan 2013.
Translational strategies and systems biology insights for blood-brain barrier opening and delivery in brain tumors and Alzheimer's disease
Biomed Pharmacother. 2023 Sep 11;167:115450. doi: 10.1016/j.biopha.2023.115450. Online ahead of print.ABSTRACTThe blood-brain barrier (BBB) plays a critical role in determining the effectiveness of systemic treatments for brain diseases. Over the years, several innovative approaches in BBB opening and drug delivery have been developed and progressed into clinical testing phases, including focused ultrasound (FUS) with circulating microbubbles, mannitol-facilitated delivery of anti-neoplastic drugs, receptor-mediated transcytosis (RMT) by antibody-drug conjugates (ADCs), and viral vectors for gene therapy. We provided a com...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Gefei Song Pierce Plumlee Ju Young Ahn Stephen Tc Wong Hong Zhao Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors
We examined the hippocampal inflammation-related gene expression changes over time. The expression of interleukin-1β (Il1b) and tumor necrosis factor α (Tnfa) was rapidly enhanced and sustained until 24 h after LPS administration, whereas the expression of Il6 was transiently induced at approx. 6 h. IL-6-dependent downstream signaling of transducer and activator of transcription 3 (STAT3) was also activated approx. 3-6 h after LPS treatment. The expression of innate immune genes including interferon-induced transmembrane proteins such as interferon-induced transmembrane protein 1 (Ifitm1) and Ifitm3 and complement factor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Sumire Matsuura Yuki Nishimoto Akane Endo Hirono Shiraki Kanzo Suzuki Eri Segi-Nishida Source Type: research
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors
We examined the hippocampal inflammation-related gene expression changes over time. The expression of interleukin-1β (Il1b) and tumor necrosis factor α (Tnfa) was rapidly enhanced and sustained until 24 h after LPS administration, whereas the expression of Il6 was transiently induced at approx. 6 h. IL-6-dependent downstream signaling of transducer and activator of transcription 3 (STAT3) was also activated approx. 3-6 h after LPS treatment. The expression of innate immune genes including interferon-induced transmembrane proteins such as interferon-induced transmembrane protein 1 (Ifitm1) and Ifitm3 and complement factor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Sumire Matsuura Yuki Nishimoto Akane Endo Hirono Shiraki Kanzo Suzuki Eri Segi-Nishida Source Type: research
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors
We examined the hippocampal inflammation-related gene expression changes over time. The expression of interleukin-1β (Il1b) and tumor necrosis factor α (Tnfa) was rapidly enhanced and sustained until 24 h after LPS administration, whereas the expression of Il6 was transiently induced at approx. 6 h. IL-6-dependent downstream signaling of transducer and activator of transcription 3 (STAT3) was also activated approx. 3-6 h after LPS treatment. The expression of innate immune genes including interferon-induced transmembrane proteins such as interferon-induced transmembrane protein 1 (Ifitm1) and Ifitm3 and complement factor...
Source: Biological and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Sumire Matsuura Yuki Nishimoto Akane Endo Hirono Shiraki Kanzo Suzuki Eri Segi-Nishida Source Type: research
