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Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Development of a Rabbit Human Glioblastoma Model for Testing of Endovascular Selective Intra-Arterial Infusion (ESIA) of Novel Stem Cell-Based Therapeutics
CONCLUSIONS: The intracranial immunosuppressed rabbit human GBM model allows testing of ESIA infusion of novel therapeutics (e.g., MSC-D24) in a clinically relevant fashion.PMID:37603323 | DOI:10.1093/neuonc/noad152
Source: Ann Oncol - August 21, 2023 Category: Cancer & Oncology Authors: Peter Kan Visish M Srinivasan Joy Gumin Roberto Garcia Stephen R Chen Jeremiah N Johnson Dalis E Collins Melissa M Chen Daniel Ledbetter Jason Huse Zean Aaron Evan Luna Ariadna Robledo Viren Vasandani Abhijit Rao Sanjay K Singh Elizabeth J Shpall Juan Fue Source Type: research
Oncolytic viruses as treatment for adult and pediatric high-grade gliomas: On the way to clinical success
Int Rev Cell Mol Biol. 2023;379:169-188. doi: 10.1016/bs.ircmb.2023.04.001. Epub 2023 Apr 26.ABSTRACTHigh-grade gliomas (HGGs) are the most common and aggressive primary brain tumors in both adult and pediatric populations. Despite the multimodal treatment modality currently available for HGG, the prognosis is dismal, with a low overall survival rate at two years after diagnosis. In the last decade, oncolytic virotherapy has emerged as a promising and feasible therapeutic tool in management of these tumors due to its oncolytic and immunostimulatory properties. Various oncolytic viruses, such as herpes simplex virus, adenov...
Source: International Review of Cell and Molecular Biology - August 4, 2023 Category: Cytology Authors: Irati Herv ás-Corpión Marta M Alonso Source Type: research
